OCT 05, 2018 05:56 PM PDT

What is Site-directed Mutagenesis?

WRITTEN BY: Carmen Leitch

Site-directed mutagenesis is a common tool in the molecular laboratory. Basically, it’s an easy way to create a specific mutation, usually, one that has been associated with a disease, in a single gene. That mutated gene can then be used to express a mutant protein, and the behavior of that protein can be studied, which can lead to important insights into disease pathology.

It’s now relatively simple to perform site-directed mutagenesis, but someone first had to pioneer the process. In October 1993, Dr. Michael Smith received a Nobel Prize for doing so. Learn more about it from Dr. Smith himself and others in this quick video.

About the Author
  • Experienced research scientist and technical expert with authorships on 28 peer-reviewed publications, traveler to over 60 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
SEP 09, 2018
Videos
SEP 09, 2018
Mass elephant poaching in Botswana
Ninety dead elephants have been found in Botswana recently, most large bulls whose tusks have been removed. Botswana has historically had a zero-tolerance...
SEP 16, 2018
Plants & Animals
SEP 16, 2018
If You Thought T. Rex Was Big, Then Watch This
Dinosaur-themed Hollywood movies have hyped up Tyrannosaurus Rex, making it seem like the king of all dinosaurs. But realistically, T. Rex was quite small...
SEP 17, 2018
Videos
SEP 17, 2018
How THC Binds to Cannabinoid Receptors in the Brain
Seconds after marijuana is consumed it begins to affect your brain. The main cannabinoid produced by the cannabis plant is called THC (tetrahydrocanna...
SEP 24, 2018
Videos
SEP 24, 2018
Restaurants use psychology to make you spend more money
Have you ever gone out to a restaurant and ended up ordering way more than you expected to, only to get the bill at the end of dinner and be totally blinds...
OCT 10, 2018
Space & Astronomy
OCT 10, 2018
OnSight Lets Scientists Study the Martian Surface with Virtual Reality
NASA’s Curiosity rover has been physically exploring the surface of Mars since 2012, but as it rolls along, it sends surface data back to scientists...
OCT 12, 2018
Videos
OCT 12, 2018
Don't Mess With Microbes
Researchers demonstrate why antibiotics should not be used casually....
Loading Comments...