OCT 05, 2018 5:56 PM PDT

What is Site-directed Mutagenesis?

WRITTEN BY: Carmen Leitch

Site-directed mutagenesis is a common tool in the molecular laboratory. Basically, it’s an easy way to create a specific mutation, usually, one that has been associated with a disease, in a single gene. That mutated gene can then be used to express a mutant protein, and the behavior of that protein can be studied, which can lead to important insights into disease pathology.

It’s now relatively simple to perform site-directed mutagenesis, but someone first had to pioneer the process. In October 1993, Dr. Michael Smith received a Nobel Prize for doing so. Learn more about it from Dr. Smith himself and others in this quick video.

About the Author
BS
Experienced research scientist and technical expert with authorships on over 30 peer-reviewed publications, traveler to over 70 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
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