AUG 30, 2018 1:00 AM CEST

Early disease detection performing NMR - Understanding how a better analysis of metabolites in serum and urine can help (For research use only)

Speakers
  • Professor of Chemical Biology and the Head of the Division of Computational and Systems Medicine at Imperial College London
    BIOGRAPHY
  • Professor of Chemistry and Co-founder/Director of the Center of Magnetic Resonance (CERM) at the University of Florence
    BIOGRAPHY

Abstract
DATE: August 30, 2018
TIME: 10:00am CEST, 4:00pm CST
 
Quantification in body fluids like plasma/serum and urine is valuable because it provides information on endogenous compounds produced in the body as well as capturing drugs and their metabolites, in addition lifestyle-based molecules can be recognized, be it from nutritional habits or physical activity. By performing NMR on body fluid samples, the role of the metabolites is identified in a multitude of   conditions, like IBD, cardiovascular, obesity and diabetes. Being able to profile the metabolome and its changes over time in body fluids is particularly relevant in the clinical area as a potential diagnostic tool and in early disease detection and prevention either on a personal or population wide level.
 
Standardized NMR can identify metabolites in a wide concentration range in body fluids.    Highly efficient analysis software provided by Bruker can quantify a multitude of small molecules in urine and plasma/serum while delivering also lipoprotein subclass information in the latter in a fully automated approach  
 
Prof. Luchinat will discuss the importance of targeted and nontargeted metabolomics NMR analysis in his research and highlight the impact of quantification information generated under standardized conditions on the Bruker IVDr platform.  He will show the effect of being able to detect small molecules as well as lipoprotein information for the development of diagnostic tools e.g. in cardiovascular or cancer research.
 
Additionally, in this webinar Prof. Holmes, will highlight the reproducibility and transferability of NMR in a large ring test, compare quantification routines and their reliability and relevance to her research. She will also show examples using targeted and non-targeted analysis out of her research. The suitability of NMR for high throughput screening is discussed.
 
In this webinar, viewers can expect a discussion into how new methods of determining the concentration and type of metabolites in plasma/serum and urine have distinct advantages over current conventional methods, and how this new method can be used as a large-scale screening technique. Viewers can also expect to see how metabolic research can use NMR as a leading analysis tool for body fluids.
 
The main points that viewers can take away from the webinar will be:
  • The clinical translation of metabolomics research: metabolomics as a potential   diagnostic tool for disease recognition and staging.
  • Now NMR can be used in high throughput metabolomics screening.
  • The robustness of standardized NMR technology, especially with regard to reproducibility and transferability.
The webinar will be of interest to people performing human metabolomics studies and clinical trials, clinicians, metabolomics researchers who work in industry, private organisations and academia, R&D professionals, healthcare professionals, food researchers, nutritionists, analytical service providers and NMR experts
 
Important note: The methods and solutions discussed during the webinar are for research use only and not for use in clinical diagnostic procedures.

Show Resources
You May Also Like
FEB 15, 2023 7:00 AM PST
FEB 15, 2023 7:00 AM PST
Date: February 15, 2023 Time: 7:00am (PST), 10:00pm (EST), 4:00pm (CET) While not all microscopy samples can fluoresce, all can scatter light, and this scattered light can be imaged. This ha...
AUG 24, 2022 7:00 AM PDT
AUG 24, 2022 7:00 AM PDT
Date: August 24, 2022 Time: 7:00am (PDT), 10:00pm (EDT), 4:00pm (CEST) Light field microscopy was first introduced in 2006, and allows users to capture the 4D light field within the microsco...
NOV 16, 2022 7:00 PM PST
C.E. CREDITS
NOV 16, 2022 7:00 PM PST
Date: November 16, 2022 Time: 2:00pm (AEST) Date: November 17, 2022 7:00pm (PST), 10:00pm (EST), 4:00am (CET) The growth in FDA-approved cell and gene therapy products for the treatment of d...
C.E. CREDITS
Date: October 25, 2022 Time: 9:00am (PST), 12:00pm (EST), 6:00pm (CEST) Candida auris is a multi-drug resistant yeast that continues to be a global threat for infection and transmission in h...
SEP 28, 2022 9:00 AM PDT
SEP 28, 2022 9:00 AM PDT
Date: September 28, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) While COVID-19 continues to be the most pressing diagnostic focus for clinical laboratories, HIV remains a serious g...
SEP 22, 2022 9:00 AM PDT
SEP 22, 2022 9:00 AM PDT
Date: September 22, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Optimizing platforms for surgical specimen collection and deep human phenotyping was used to enhance protein biomarke...
AUG 30, 2018 1:00 AM CEST

Early disease detection performing NMR - Understanding how a better analysis of metabolites in serum and urine can help (For research use only)



Show Resources
Loading Comments...
Show Resources