SEP 20, 2018 1:00 AM CEST

Cardiovascular Disease: Applying MRI to study atherosclerosis, the aortic arch and endothelial permeability in small animal models

Sponsored by: Bruker
Speaker

Abstract
DATE: September 20, 2018
TIME: 10:00am CEST, 4:00pm CST
 
Cardiovascular disease due to atherosclerosis is the leading cause of disease and mortality worldwide. So-called “vulnerable” atherosclerotic plaques are those that are likely to result in clinical events. One of the hallmarks of vulnerable plaques is increased endothelial permeability, a feature that is related to the progression of the disease across all stages of the atherosclerotic cascade.
 
Increased endothelial permeability at the beginning of atherosclerosis is believed to allow lipid deposition and plaque formation to occur. At later stages it is associated with plaque inflammation and extravasation of inflammatory cells that occurs as a plaque progresses and may eventually lead to plaque rupture. This webinar will describe the application of magnetic resonance imaging (MRI) for the characterization of increased endothelial permeability in mouse atherosclerotic plaques using the preclinical Bruker Biospec 7 Tesla horizontal 70/30 scanner and self-gating features (IntraGate). Self-gated imaging allows high-quality cardiac MRI with no additional hardware requirements (such as the use of ECG electrodes) and potential pitfalls of signal interferences and disruption and has been used in our laboratory to obtain clear imaging of the mouse aortic root.
 
The basics self-gated imaging, along with the advantages of applying this method in both cardiac and vascular MRI, will be discussed.  For example, this flexible tool allows high quality, high resolution pre-clinical cardiac and vascular imaging without the need for ECG triggering, meaning no electrodes and no gating with a device is needed.
 
Key topics
 
  • Applying MRI to study atherosclerosis in the mouse aortic root, with a focus on endothelial permeability
  • 2D dynamic contrast enhanced (DCE) MRI and 3D T1 mapping of the aortic root and ascending aorta using Bruker BioSpec 70/30 USR and self-gated imaging (IntraGate software package)
  • The advantages of using self-gated techniques for cardiac and vascular imaging
  • The flexibility these techniques provide for individuals working in pre-clinical imaging
 
Who should attend?
 
The webinar will be useful to anybody interested in cardiac and vascular imaging of small animals, particularly using MRI. It would also be useful for researchers who image larger animals on clinical scanners but who are interested in smaller animal imaging where more in-depth mechanistic studies can be conducted. The webinar will also appeal to anyone interested in the pathology of cardiovascular disease.

Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
OCT 20, 2021 10:00 AM PDT
C.E. CREDITS
OCT 20, 2021 10:00 AM PDT
Date: October 20, 2021 Time:10:00am (PDT), 1:00pm (EDT) As the prevalence of Diabetes continues to rise in many areas across the globe, healthcare providers continue to look for methods that...
APR 21, 2021 5:00 PM CEST
APR 21, 2021 5:00 PM CEST
Date: April 21, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Spatial Answers Trilogy - Spatial Answers in Immunology Immunology Researchers share their Spatial Discoveries in SARS-C...
SEP 29, 2021 11:00 AM PDT
C.E. CREDITS
SEP 29, 2021 11:00 AM PDT
Date: Septembr 29, 2021 Time: 11:00am (PDT), 2:00pm (EDT) 3D cell models are becoming increasingly popular for studying complex biological effects, tissue functionality, and diseases. While...
SEP 20, 2018 1:00 AM CEST

Cardiovascular Disease: Applying MRI to study atherosclerosis, the aortic arch and endothelial permeability in small animal models

Sponsored by: Bruker

Specialty

Cancer Research

Biochemistry

Immunology

Molecular Biology

Laboratory Testing

Cell Biology

Clinical Diagnostics

Clinical Research

Animal Models

Biotechnology

Cardiology

Cancer Diagnostics

Molecular Diagnostics

Clinical Chemistry

Medicine

Geography

North America38%

Europe31%

Asia22%

South America4%

Africa3%

Oceania2%

Registration Source

Website Visitors75%

Email Promotions11%

WAVE Newsletter Promotion10%

Social Media Promotions3%

Website Banners1%

Other2%

Job Title

Student19%

Medical Laboratory Technician16%

Educator/Faculty13%

Research Scientist11%

Medical Doctor/Specialist8%

Facility/Department Manager7%

Clinical Laboratory Scientist5%

Scientist5%

Lab Management5%

Executive5%

Post Doc3%

Engineer2%

Animal Care Lab Technician1%

Organization

Academic Institution26%

Hospital15%

Research Institute12%

Clinical Laboratory8%

Medical Center6%

Medical School6%

Biotech Company4%

Life Science Company3%

Government3%

Industrial Company2%

Pharmaceutical Company2%

Animal Hospital2%

Government/public2%

Consultant1%

Other4%


Show Resources
Loading Comments...
Show Resources