NOV 14, 2018 9:00 AM PST

Accelerating Cancer Research and Clinical Innovations Using OncoLand

Sponsored by: QIAGEN
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Sr. Scientist, Bioinformatics, QIAGEN
    Biography
      Dr. Zhou is a professional scientist with more than 10 years of experience in oncology, cancer genetics, and preclinical drug discovery. She previously works as research associate in the Lineberger Cancer Center of University of Carolina at Chapel Hill, where her interests are centered around molecular mechanisms of breast cancer and prostate cancer using animal models. Her experiences in industry includes target discovery and validation, cell-based assay development, and small molecules screening. Currently, Bing is managing Oncoland curation team within OmicSoft, a QIAGEN company. So far, OncoLand curation team has curated thousands of projects from cancer genomics consortia as well as public data repositories. Her knowledge on cancer biology and clinical ontologies has supported the establishment of internal curation standards.

    Abstract

    With significant decrease in the cost of sequencing in numerous commercial as well as cancer center–driven initiatives, genomic profiling is increasingly becoming routine across multiple cancer types. There is a large amount of diverse omic-data that has been generated, which are either publicly accessible through numerous repositories or managed through controlled data archives. However, the sheer volume and diversity of the data presents a significant challenge in data management and analysis. 

    OncoLand is an integrated oncology genomics repository and visualization platform. Feature tremendous numbers of consortia data and tens of thousands of processed and carefully curated cancer genomics datasets from public domains. The OncoLand tool enables investigators to easily query and navigate a gene or sets of genes of interest in multiple tumors across data from different platforms, including DNA mutation, gene expression and fusion, copy number, protein, and methylation. The built-in Omicsoft Genome Browser (OGB) allows a detailed view of coverage, gene fusions and alternatively spliced isoforms. OncoLand contains a variety of modules for integrative analysis, comparisons, and clinical associations explorations. OncoLand has become an invaluable platform to accelerate successful cancer research and clinical innovations.


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