NOV 09, 2021 9:00 AM PST

Advances in Celiac Disease Testing: From method validation to serological diagnosis

Sponsored by: Bio-Rad Laboratories
C.E. Credits: P.A.C.E. CE Florida CE
Speakers

Abstract
Date:  November 9, 2021
Time: 9:00am (PDT),  12:00pm (EDT)
 
Celiac disease (CD) serology plays an important role in CD screening, diagnosis and monitoring of dietary adherence and ongoing mucosal inflammation. Numerous societies have universally recommended CD screening in gluten-exposed individuals through serologic testing for IgA autoantibodies to tissue transglutaminase (tTG IgA), as the most sensitive screening test. The North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHN) has recommended a biopsy in symptomatic children with positive tTG IgA or asymptomatic at-risk children with positive tTG IgA or tTG IgG. The European Society Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) has proposed a no-biopsy option for children with tTG IgA result of ≥10 times the upper limit of normal (10XULN), if endomysial IgA antibody (EMA IgA) is positive in a second blood sample Since the analytical performance of serology assays has not been standardized, large inter-assay variability and variable concordance with confirmatory methods can be found. Therefore, assays and testing algorithms should be carefully evaluated for clinical and analytical performance by testing laboratories. In particular, the dose-response relationships amongst tTG IgA assays are often non-linear and therefore, implementation of the 10X ULN cut-off should be carefully evaluated. This presentation will provide an overview of analytical methods used for serologic evaluation of celiac disease, their strengths and limitations, as well as important analytical considerations of clinical impact when one is validating a new method.
 
Learning Objectives
  • Describe analytical methods for celiac disease serology used in clinical laboratories
  • Discuss challenges in implementing a serological diagnosis for celiac disease.
  • Describe two considerations for validating a new cut-off in an assay.
 
 
Webinars will be available for unlimited on-demand viewing after live event.
 
LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.

Show Resources
You May Also Like
NOV 30, 2021 10:00 AM PST
C.E. CREDITS
NOV 30, 2021 10:00 AM PST
Date: November 30, 2021 Time: 10:00am (PDT), 1:00pm (EDT) The prevalence of thyroid disease worldwide has served as a catalyst for healthcare providers to study various tools and methods to...
JUN 28, 2022 6:45 AM PDT
JUN 28, 2022 6:45 AM PDT
Date: June 28, 2022 Time: 3:00pm (BST), 4:00pm (CET), 9:00am (CST), 7am (PST) Light-sheet microscopy is an extremely versatile imaging technique with a vast range of implementations that are...
MAR 23, 2022 11:00 AM PDT
MAR 23, 2022 11:00 AM PDT
Date: March 23, 2021 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CEDT) In this presentation, Dr. Middleton will review the development and deployment of large-scale saliva-based COVID-19 test...
JUN 21, 2022 6:00 AM PDT
JUN 21, 2022 6:00 AM PDT
Date: June 21, 2022 Time: 6:00am (PDT), 9:00am (EDT), 3:00pm (CEST) The global understanding and practice of medicine is currently undergoing a revolutionary change. This shift to precision...
MAY 17, 2022 9:00 AM PDT
MAY 17, 2022 9:00 AM PDT
Date: May 17, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 8:00pm (CEST) Gene therapeutics have great potential to treat many severe diseases in an unprecedented, targeted manner. The biopharmace...
DEC 09, 2021 6:00 AM PST
C.E. CREDITS
DEC 09, 2021 6:00 AM PST
Date: December 9, 2021 Time: 6:00am (PDT), 9:00 am (EDT) As the number of biotherapeutic candidates in development is increasing, the requirements of analytical tools to understand the molec...
Loading Comments...
Show Resources