SEP 12, 2018 08:00 AM PDT

Advancing precision immunotherapy through next generation sequencing of T-cell receptors: Part II

Speakers
  • Staff Scientist, Bioinformatics, Thermo Fisher Scientific
    Biography
      Dr. Looney is an accomplished computational biologist and immunologist with expertise in methods and applications of B and T cell receptor sequencing, including biomarker discovery and assay development. He is currently a Staff Scientist and Informatics Lead for Immune Repertoire Sequencing within the Clinical Sequencing Division at Thermo Fisher Scientific. Dr. Looney's interests and specialties are centered around repertoire analysis for immuno-oncology, autoimmunity and infectious disease translational research.

    Abstract:
    DATE: September 12, 2018
    TIME: 08:00am PDT, 11:00am EDT
     
    Immuno-Oncology Webinar Series (#3 of 3)
     
    In the final presentation of this webinar series, we will continue our discussions of recent advancements in the application of next-generation sequencing of T cell receptor beta (TCRB) chain repertoires to precision immunotherapy. Last month, Dr. Looney highlighted novel applications of long-amplicon TCRB sequencing. This month we introduce a newly launched short-amplicon TCRB sequencing assay designed to interrogate the TCRB CDR3 region from fresh or formalin-fixed paraffin-embedded (FFPE) samples. Dr. Looney will present data suggesting that short-amplicon TCRB repertoire sequencing of FFPE samples may be used to characterize T cell responses to tumor antigens through the assessment of T cell expansion, diversity and receptor convergence. Additionally, short-read sequencing of the peripheral blood may enable detection of low frequency malignant T cell clones for future minimal residual disease (MRD) monitoring applications.
     
    Learning Objectives:
    • Understand new applications of T cell receptor sequencing to immunotherapy translational research.
    • Describe the advantages of short-amplicon TCRB sequencing via Ion Torrent for characterization of the tumor microenvironment
     
    Register for our 3 Part Series here:

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