JUL 18, 2018 08:00 AM PDT
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Advancing precision immunotherapy through next-generation sequencing of T cell receptors.
SPONSORED BY: Thermo Fisher Scientific Ion Torrent
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  • Staff Scientist, Bioinformatics, Thermo Fisher Scientific
      Dr. Looney is an accomplished computational biologist and immunologist with expertise in methods and applications of B and T cell receptor sequencing, including biomarker discovery and assay development. He is currently a Staff Scientist and Informatics Lead for Immune Repertoire Sequencing within the Clinical Sequencing Division at Thermo Fisher Scientific. Dr. Looney's interests and specialties are centered around repertoire analysis for immuno-oncology, autoimmunity and infectious disease translational research.


    DATE: July 18, 2018
    TIME: 08:00AM PDT

    This webinar will review recent advancements in the application of next-generation sequencing of T cell receptor beta (TCRB) chain repertoires towards predictive and mechanistic biomarker discovery for cancer immunotherapy. Dr. Looney will focus on immunotherapy biomarker applications of the Ion AmpliSeq Immune Repertoire Assay Plus, TCR Beta, which provides coverage of the CDR1, 2 and 3 regions of the rearranged TCRB chain. He will highlight recent data from individuals receiving checkpoint blockade immunotherapy for cancer which suggest that TCRB repertoire sequencing of pre-treatment peripheral blood may be used to identify predictive biomarkers for immune-mediated adverse events and objective clinical response.

    Learning Objectives:

    • Understand current applications of T cell receptor sequencing to immunotherapy translational research.
    • Describe the advantages of long-amplicon TCRB sequencing via Ion Torrent for immunotherapy biomarker discovery from peripheral blood.

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