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JUN 20, 2019 12:00 PM PDT

Antiplatelet Agents for Secondary Stroke Prevention - Can We Be More Precise?

C.E. Credits: P.A.C.E. CE Florida CE
Speaker

Abstract

Clopidogrel, an antiplatelet agent frequently used for secondary stroke prevention, is a prodrug that requires both sufficient intestinal absorption and hepatic modification to produce its active metabolite. An individual's ABCB1 alleles affect clopidogrel absorption, while one's CYP2C19 alleles affect activation of this prodrug. Herein, we explore the role of platelet function assays and genotyping of CYP2C19 and ABCB1 in terms of clopidogrel absorption and activation, and its efficacy in platelet inhibition through three patients who experienced recurrent ischemic stroke despite adherence to clopidogrel. 

Learning Objectives: 

1. Describe the role that platelet function phenotype may play in secondary stroke prevention antiplatelet selection in the future.
2. Describe the role that CYP2C19 and/or ABCB1 genotypes may play in secondary stroke prevention antiplatelet selection in the future.


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JUN 20, 2019 12:00 PM PDT

Antiplatelet Agents for Secondary Stroke Prevention - Can We Be More Precise?

C.E. Credits: P.A.C.E. CE Florida CE

Specialty

Molecular Biology

Clinical Research

Laboratory Testing

Biomarkers

Cancer Research

Molecular Diagnostics

Clinical Diagnostics

Drug Discovery

Cell Biology

Clinical Chemistry

Immunology

Biology

Pcr/rt-Pcr/real-Time Pcr

Biochemistry

Medicine

Geography

North America70%

Asia30%

Registration Source

Website Visitors100%

Job Title

Clinical Laboratory Scientist44%

Medical Laboratory Technician22%

Educator/Faculty22%

Lab Management11%

Organization

Hospital40%

Clinical Laboratory30%

Academic Institution20%

Medical Center10%


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