FEB 08, 2018 01:30 PM PST

Applications of Preclinical Translational Imaging Technologies for Improved Modeling and Decision Making

  • Senior Principle Research Scientist, AbbVie
      Paul is a Senior Principle Research Scientist based at AbbVie, Inc. His research focuses on molecular imaging and utilizes translational imaging modalities for pre-clinical development such as PET/SPECT/CT/MRI, ultra-high frequency ultrasound, confocal laser endomicroscopy, photoacoustic technologies, and OCT. Paul has earned degrees in electrical engineering (B.S), doctor of veterinary medicine (DVM), and in biomedical engineering (PhD). He is a certificate holder of Nanobiology from the University of Michigan Rackham Graduate School and a Diplomate of the American College of Laboratory Animal Medicine. He previously served as the Director of Vaccine Development at the Michigan Nanotechnology Institute for Medicine and Biological Sciences at the University of Michigan (Ann Arbor, MI), and the Associate Director of the In Vivo Translational Core for the University of Michigan Medical School.


    Preclinical translational imaging, and specifically molecular imaging methods such as positron emission tomography (PET) or single photon emission computed tomography (SPECT) as well as magnetic resonance imaging (MRI) are extremely useful tools in the drug discovery and development process.  Continuous progress in modern imaging technologies holds a great potential to extend efficiencies to drug discovery and translation and to reduce clinical attrition.  Newer technologies such as photoacoustic tomography and confocal laser endomicroscopy lend the ability to identify critical and highly specific biomarker information for oncology, neurology, and immunology strategies.  These approaches can significantly enhance preclinical and translational research. The discussion will provide an overview of the strengths of different imaging technologies and will focus on scientific translational applications in oncology, neurology, immunology, and safety. 

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