There is growing pressure to implement new generation sequencing platform in hospital emergency rooms. The utility would be obvious: identifying unknown pathogens form cerebrospinal fluid/plasma/body fluids and guiding next step in therapy. What is exactly preventing us in taking this step, if we know that billions of dollars is/was spent on revealing cancer-relevant sequence-signatures using the same technology? And one vanishes from cancer much slower comparing to 24-48h time-window of life under unrelieved life-threatening infection. What went wrong in cashing in technological advance?