It has only been in the last 20 years that we, the scientific/medical community, have appreciated the role of the endogenous Cannabinoid system (ECS) in maintaining a healthy immune system and brain. More recently, we recognized that the ECS is critical for stem cell development and homeostasis. The phytocannabinoid, THC is a modulator of Hematopoietic Stem Cells (HSC). It acts in part via stimulation of TGF beta production. The modulation of TGF beta, HSC and the NFkB by other natural product immunotherapy via some of the same pathways as THC suggest opportunities for synergy and decreasing psychoactive effects.
Combinations of phytocannabinoiss can be used as stem cell and immune therapy in combination with other natural products and chemotherapy as curative treatment strategies for cancer, AIDS, Autoimmune disease and chronic inflammatory diseases. Moreover, Evidence is accumulating that THC is actually reduces opioid addiction by modulating endogenous opioids. Endogenous opioids are peptides derived from food which can also modulate immune cells including hematopoietc stem cells and be valuable therapeutics against HIV/AIDS and Cancer as our collaborator, Candace Pert demonstrated in the 1980s when she/we developed peptide T as an AIDS and cancer therapeutic (book Molecules of Emotion). Endocannabinoids, phyto-cannabinoids, and opioids modulate the immune system, hematopoietic and mesenchymal stem cells, it may also modulate the opioid pathways to reduce addiction.