NOV 08, 2017 12:00 PM PST

Combined immunohistochemistry and RNA in situ hybridization to elucidate tumor molecular heterogeneity in prostate cancer

Speaker

Abstract

Currently, prostate cancer is the second leading cause of death from cancer in North America, the most frequent malignancy in men from all ethnicities, surpassing lung cancer. Prostate tumors are highly heterogeneous and there are many studies evaluating the molecular profile or ‘fingerprint’ of prostate cancer.  Conventional analysis reviews the protein expression of key markers via serum analysis and immunohistochemistry (IHC) of the biopsy.  In this presentation we will review how RNA in situ hybridization (ISH) analysis of prostate cancer can unravel the molecular heterogeneity of the tumor, identify molecular subsets and detect key fusions and mutations of the RNA.  We will also present a comparison of IHC and ISH technology and the combination of dual color IHC and dual color ISH can be used to enhance simultaneous evaluation of DNA, RNA and protein, revealing the molecular profile of prostate cancer.


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NOV 08, 2017 12:00 PM PST

Combined immunohistochemistry and RNA in situ hybridization to elucidate tumor molecular heterogeneity in prostate cancer


Specialty

Research

Health

Life Science

Immunohistochemistry

Cell Biology

Antibodies

Research And Development

Blood

Digital Pathology

Immunology

Biomarkers

University

Cancer

Molecular Biology

Histology

Geography

North America50%

Europe33%

Asia17%

Registration Source

Website Visitors100%

Job Title

Medical Laboratory Technician67%

Pathologist33%

Organization

Hospital33%

Pharmaceutical Company17%

Research Institute17%

Academic Institution17%

Manufacturer - Other17%


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