OCT 25, 2018 8:00 AM PDT

Disease modeling and cancer therapy in stem cell-derived 3D organoid systems

  • Postdoctoral researcher, Hubrecht Institute, Hans Clevers Lab
      Devanjali is currently pursuing her Postdoctoral research in the lab of Prof. Hans Clevers (Netherlands), where she is using human tissue derived 3D organoid cultures to study host-microbiome interactions, infectious diseases and cancer. She received her PhD from University of Heidelberg (Germany) in 2015 from the lab of Prof. Bruce Edgar. During her PhD, she generated methods to isolate and profile rare cell types and tumor cells from the fruit fly midgut and generated the transcriptome profiles of the cells of the adult Drosophila intestinal epithelium.

    DATE: October 25, 2018
    TIME:  08:00am PDT, 11:00am EDT
    While the significance of the microbiome is unprecedented, a thorough study to dissect the role of individual populations of the natural gut microbiome in healthy and diseased states is still lacking. Currently available in-vitro models of the human intestine have certain limitations, e.g., lack of immune cells or microbiota. Therefore, systems closely mirroring the human intestine are needed to gain a better understanding of intestinal dysfunction, host - pathogen interactions and for the development of more effective therapies for cancer. It is important to establish a patient derived, fast and efficient system which would mimic the in-vivo architecture in humans and permit precise studies on interactions of the gut microbes with the epithelium and the immune cells. The in-vitro 3D “mini-gut” system developed in the Clevers lab displays many important functions of the normal intestinal epithelium. Along with the developed toolbox for the analysis of these organoids (including FACS-based cell sorting, confocal imaging, RNA Sequencing, mass-spec proteomics and CRISPR-Cas9), it has proven to serve as a powerful system to investigate regulatory and pathological mechanisms of the intestinal epithelium on a molecular level.
    To this end, we are developing a triple co-culture system of epithelial cells, immune cells and microbes to better understand the functional role of the gut microbiota, enabling personalized healthcare for the benefit of patients suffering from GI tract diseases. It might be possible in the future to determine the microbiome composition of cancer patients and provide personalized immunotherapy drug treatment.
    Learning Objectives:
    • Organoids can be used for studying cancer and hereditary diseases, as well as in the examination of host cell–microorganism interactions. 
    • Patient-derived organoids may enable personalized medicine.
    • Identify categories of individuals at risk of acquiring HDV infection.

    Show Resources
    You May Also Like
    DEC 02, 2020 8:00 AM PST
    DEC 02, 2020 8:00 AM PST
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    SEP 10, 2020 9:00 AM PDT
    SEP 10, 2020 9:00 AM PDT
    Date: September 10, 2020 Time: 9:00am (PDT), 12:00pm (EDT) Osmolality testing is relevant throughout the entire bioprocessing workflow. As customers look to refine mAb and gene therapy workf...
    OCT 08, 2020 7:00 AM PDT
    OCT 08, 2020 7:00 AM PDT
    DATE: October 8, 2020 TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop thinking about ho...
    NOV 18, 2020 8:00 AM PST
    NOV 18, 2020 8:00 AM PST
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    NOV 16, 2020 8:00 AM PST
    NOV 16, 2020 8:00 AM PST
    Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
    OCT 29, 2020 6:00 AM PDT
    OCT 29, 2020 6:00 AM PDT
    Date: October 29, 2020 Time: 6:00am (PDT), 9:00am (EDT), Chronic inflammation can occur as a result of a combination of genetic predispositions and environmental factors. Epigenetic modifica...
    OCT 25, 2018 8:00 AM PDT

    Disease modeling and cancer therapy in stem cell-derived 3D organoid systems


    Cancer Research

    Cell Biology

    Cell Culture

    Molecular Biology


    Cancer Therapeutics

    Cancer Diagnostics

    Stem Cell Technologies


    Cell Signaling / Transduction




    Gene Expression

    Drug Discovery


    North America35%



    South America5%



    Registration Source

    Website Visitors54%

    Email Promotions25%

    WAVE Newsletter Promotion6%

    Website Banners4%

    Social Media Promotions3%

    Client/Sponsor Promotions2%

    Trending Newsletter Promotion1%


    Job Title


    Research Scientist22%


    Post Doc10%


    Facility/Department Manager6%


    Medical Laboratory Technician5%

    Medical Doctor/Specialist4%



    Lab Management1%

    Clinical Laboratory Scientist1%


    Academic Institution27%

    Research Institute17%

    Biotech Company10%



    Clinical Laboratory5%

    Medical School5%

    Life Science Company4%

    Medical Center4%

    Pharmaceutical Company3%

    Non-Profit Organization2%

    Industrial Company1%

    Contract Research Organization (Cro)1%

    Private Practice1%


    Show Resources
    Loading Comments...
    Show Resources
    • See more