OCT 25, 2018 8:00 AM PDT

Disease modeling and cancer therapy in stem cell-derived 3D organoid systems

Speaker

Abstract
DATE: October 25, 2018
TIME:  08:00am PDT, 11:00am EDT
 
While the significance of the microbiome is unprecedented, a thorough study to dissect the role of individual populations of the natural gut microbiome in healthy and diseased states is still lacking. Currently available in-vitro models of the human intestine have certain limitations, e.g., lack of immune cells or microbiota. Therefore, systems closely mirroring the human intestine are needed to gain a better understanding of intestinal dysfunction, host - pathogen interactions and for the development of more effective therapies for cancer. It is important to establish a patient derived, fast and efficient system which would mimic the in-vivo architecture in humans and permit precise studies on interactions of the gut microbes with the epithelium and the immune cells. The in-vitro 3D “mini-gut” system developed in the Clevers lab displays many important functions of the normal intestinal epithelium. Along with the developed toolbox for the analysis of these organoids (including FACS-based cell sorting, confocal imaging, RNA Sequencing, mass-spec proteomics and CRISPR-Cas9), it has proven to serve as a powerful system to investigate regulatory and pathological mechanisms of the intestinal epithelium on a molecular level.
 
To this end, we are developing a triple co-culture system of epithelial cells, immune cells and microbes to better understand the functional role of the gut microbiota, enabling personalized healthcare for the benefit of patients suffering from GI tract diseases. It might be possible in the future to determine the microbiome composition of cancer patients and provide personalized immunotherapy drug treatment.
 
Learning Objectives:
  • Organoids can be used for studying cancer and hereditary diseases, as well as in the examination of host cell–microorganism interactions. 
  • Patient-derived organoids may enable personalized medicine.
  • Identify categories of individuals at risk of acquiring HDV infection.

Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
APR 21, 2021 5:00 PM CEST
APR 21, 2021 5:00 PM CEST
Date: April 21, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Spatial Answers Trilogy - Spatial Answers in Immunology Immunology Researchers share their Spatial Discoveries in SARS-C...
SEP 29, 2021 11:00 AM PDT
C.E. CREDITS
SEP 29, 2021 11:00 AM PDT
Date: Septembr 29, 2021 Time: 11:00am (PDT), 2:00pm (EDT) 3D cell models are becoming increasingly popular for studying complex biological effects, tissue functionality, and diseases. While...
NOV 17, 2021 8:00 AM PST
C.E. CREDITS
NOV 17, 2021 8:00 AM PST
Date: November 17, 2021 Time: 8:00am (PDT), 11:00am (EDT) From waste disposal to promising biomarkers and therapeutic agents, exosomes and other extracellular vesicles are valuable in resear...
OCT 25, 2018 8:00 AM PDT

Disease modeling and cancer therapy in stem cell-derived 3D organoid systems


Specialty

Cancer Research

Cell Biology

Cell Culture

Molecular Biology

Biotechnology

Cancer Therapeutics

Cancer Diagnostics

Stem Cell Technologies

Biomarkers

Cell Signaling / Transduction

Immunology

Oncology

Genetics

Gene Expression

Drug Discovery

Geography

North America35%

Europe33%

Asia18%

South America5%

Africa4%

Oceania3%

Registration Source

Website Visitors54%

Email Promotions25%

WAVE Newsletter Promotion6%

Website Banners4%

Social Media Promotions3%

Client/Sponsor Promotions2%

Trending Newsletter Promotion1%

Other4%

Job Title

Student24%

Research Scientist22%

Post Doc10%

Scientist10%

Educator/Faculty7%

Facility/Department Manager6%

Medical Laboratory Technician5%

Executive5%

Medical Doctor/Specialist5%

Marketing/Sales2%

Biologist1%

Lab Management1%

Clinical Laboratory Scientist1%

Organization

Academic Institution27%

Research Institute16%

Biotech Company10%

Hospital6%

Government5%

Clinical Laboratory5%

Medical School5%

Life Science Company4%

Medical Center4%

Pharmaceutical Company3%

Non-Profit Organization2%

Industrial Company1%

Contract Research Organization (Cro)1%

Private Practice1%

Other5%


Show Resources
Loading Comments...
Show Resources