MAR 04, 2015 08:00 AM PST

Diversity of extracellular vesicles and their cargo in cell-to-cell communication

Speakers
  • Professor, Department of Internal Medicine, University of Gothenburg
    Biography
      Jan Lötvall is a Professor at the Department of Internal Medicine at University of Gothenburg since 2002, and led research in 2007 that showed exosomes can transfer functional RNA molecules between cells (Nature Cell Biology, >2300 citations). Having years of experience in translational lung research, Dr Lötvall's current research also includes the biological function of exosomes and other extracellular vesicles, and their natural ability of transferring RNA between cells. Dr. Lötvall was instrumental in starting the International Society for Extracellular Vesicles (www.isev.org), he is the current President of the organization (2012-2016), which currently attracts >700 delegates to the annual meeting, which has a more than 20% annual growth. He was also the initiating editor for the Journal of Extracellular Vesicles in 2012, the only PubMed tracked journal in the field with an unofficial Impact Factor of 10.4. Dr Lötvall has been a fellow at the Department of Thoracic Medicine, Imperial College, London (1988-1990) and the Department of Respiratory Medicine, McMaster University, Canada (1997-98), and has approximately 250 scientific papers published or in press. He is co-Editor-in-Chief of the open access scientific journal "Respiratory Research", and is the Past President of European Academy of Allergy and Clinical Immunology (EAACI).

    Abstract:
    Every cell in the body can release several types of extracellular vesicles (EVs), often called ”exosomes” or ”microvesicles”. These vesicles carry a wide array of molecules, including functional proteins and enzymes, as well as different RNA species (mRNA, microRNA and other species), all protected by a membrane lipid bilayer. EVs have the capacity to deliver molecular cargo to recipient cells by multiple pathways, including fusion at the level of the cell membrane, or by being internalized by cells. Current research is suggesting a wide diversity of extracellular vesicles , with diverse morphology according to electron microscopy studies, and difference in RNA and protein cargo according to bioinformatics analyses.

    EVs have been implicated in several ways in disease. For example, in cancer, it has been shown that the number of EVs increase in the circulation. EVs can propagate disease in several ways, for example in cancer by enhancing angiogenesis and propagating metastasis, as well inducing immune tolerance. Furthermore, several studies today have suggested that the cargo of EVs released in disease states such as cancer, including proteins and RNA, will fundamentally change, which can explain changes in function.

    This lecture will lay the background to EVs and will discuss extensively the diversity of EVs released by single cell types in culture, and diversity of EVs in body fluids, discussing their relevance for cell-to-cell communication.

    Learning Objectives:
    • Learn about the study of extracellular vesicles and their relevance for cell-to-cell communication
    • Learn about how extracellular vesicles have been implicated in several ways in disease
    • Understand the wide diversity of extracellular vesicles, with diverse morphology according to electron microscopy studies, and difference in RNA and protein cargo according to bioinformatics analyses

    Show Resources
    You May Also Like
    SEP 05, 2019 04:00 PM CEST
    C.E. CREDITS
    SEP 05, 2019 04:00 PM CEST
    DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
    AUG 27, 2019 09:00 AM PDT
    C.E. CREDITS
    AUG 27, 2019 09:00 AM PDT
    DATE: August 27, 2019 TIME: 9:00am PDT, 12:00pm EDT Immunotherapies targeting PD-1 or PD-L1 have proven remarkably effective for treating cancer in some patients, with considerabl...
    JUN 05, 2019 05:00 PM CEST
    C.E. CREDITS
    JUN 05, 2019 05:00 PM CEST
    DATE: June 5, 2019TIME: 8:00am PDT, 11:00am EDT, 5:00pm CEST Eukaryotic cell cultures respond to the most subtle influence. Apart from the risk of contamination, minimal chan...
    OCT 02, 2019 11:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    OCT 02, 2019 11:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: October 2, 2019TIME: 11:00am PDT, 2:00pm EDT Ditch the Excel spreadsheets and manage your molecular workflows entirely in your LIMS Achieve configuration of molecular workf...
    MAR 26, 2019 02:00 PM PDT
    C.E. CREDITS
    MAR 26, 2019 02:00 PM PDT
    DATE:  March 26, 2019TIME:  2:00pm PDT, 5:00pm EDT  Prostate cancer is the second most common form of cancer in males, affecting one in eight men by the time t...
    MAY 16, 2019 04:00 PM CEST
    C.E. CREDITS
    MAY 16, 2019 04:00 PM CEST
    DATE: May 16, 2019TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST The emergence of NGS is revolutionizing the microbiological sciences and transforming medicine. Deep sequencing has...
    Loading Comments...
    Show Resources