Assistant Professor, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona
BIOGRAPHY
NOV 06, 2019 10:30 AM PST
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Drug discovery and pharmacology of antivirals targeting drug-resistant influenza viruses
Presented at:
Influenza 2019
Speaker
Abstract
The efficacy of current influenza antiviral drugs is compromised by emerging drug resistance. To address this unmet medical need, we have made progress in developing novel influenza antivirals by targeting the drug-resistant mutants of M2 and the viral polymerase. In this presentation, I will introduce our work in designing inhibitors targeting the viral M2-S31N mutant proton channel and the viral polymerase PA-PB1 interactions. The designed M2-S31N inhibitors and the PA-PB1 inhibitors have been shown to inhibit drug resistant influenza viruses with potent antiviral efficacy and a high selectivity index.
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NOV 06, 2019 10:30 AM PST
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Drug discovery and pharmacology of antivirals targeting drug-resistant influenza viruses
Presented at:
Influenza 2019
Specialty
Molecular Biology
Microbiology
Clinical Diagnostics
Immunology
Biotechnology
Infectious Disease
Cancer Research
Laboratory Testing
Biochemistry
Gene Expression
Genetics
Dna
Animal Research
Biomarkers
Genomics
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