SEP 24, 2014 11:00 AM PDT

Drug Repositioning in the Era of Personalized Medicine

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  • Chief Scientific Officer, NuMedii

      Craig Webb joined the drug repurposing Stanford spin-off Numedii in July 2013 as Chief Scientific Officer. The firm combines big data, informatics and translational medicine expertise to identify new indications for existing drugs. Previously as one of the founding scientists at the Van Andel Research Institute in Michigan, Craig has spent the past 13 years building a translational research enterprise focused on the application of genomic technologies in medicine. In addition to establishing a successful basic science laboratory focused on deciphering the molecular mechanisms of tumor metastasis and drug resistance, his work also focused on the early development of precision medicine clinical trials using tumor molecular profiling. These efforts resulted in the formation of four companies in areas of bioinformatics, molecular diagnostics and clinical trial coordination (TransMed Systems, Intervention Insights, The Center for Molecular Medicine and ClinXus). Craig has a BSc in Biochemistry, a PhD in cell biology and has done post doctoral work in molecular oncology.

    This presentation will focus on NuMediis general approach towards the discovery of new therapeutic uses for existing drugs. While the business models for repurposing marketed drugs versus repositioning of proprietary shelved assets remain distinct, each with their unique opportunities and challenges, much of the underlying big data content and computational approaches used to identify lead assets in a given therapeutic area of interest remain constant. This talk will provide a high level overview of some of the tools we have deployed to identify new uses of existing drugs. A couple of use cases will be presented describing the specific use of chemogenomics and systems biology methodologies to identify new drugs/targets in Inflammatory Bowel Disease and Psoriasis.

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