SEP 24, 2014 11:00 AM PDT

Drug Repositioning in the Era of Personalized Medicine

Speaker
  • Chief Scientific Officer, NuMedii
    Biography

       
      Craig Webb joined the drug repurposing Stanford spin-off Numedii in July 2013 as Chief Scientific Officer. The firm combines big data, informatics and translational medicine expertise to identify new indications for existing drugs. Previously as one of the founding scientists at the Van Andel Research Institute in Michigan, Craig has spent the past 13 years building a translational research enterprise focused on the application of genomic technologies in medicine. In addition to establishing a successful basic science laboratory focused on deciphering the molecular mechanisms of tumor metastasis and drug resistance, his work also focused on the early development of precision medicine clinical trials using tumor molecular profiling. These efforts resulted in the formation of four companies in areas of bioinformatics, molecular diagnostics and clinical trial coordination (TransMed Systems, Intervention Insights, The Center for Molecular Medicine and ClinXus). Craig has a BSc in Biochemistry, a PhD in cell biology and has done post doctoral work in molecular oncology.
       
       

    Abstract

    This presentation will focus on NuMediis general approach towards the discovery of new therapeutic uses for existing drugs. While the business models for repurposing marketed drugs versus repositioning of proprietary shelved assets remain distinct, each with their unique opportunities and challenges, much of the underlying big data content and computational approaches used to identify lead assets in a given therapeutic area of interest remain constant. This talk will provide a high level overview of some of the tools we have deployed to identify new uses of existing drugs. A couple of use cases will be presented describing the specific use of chemogenomics and systems biology methodologies to identify new drugs/targets in Inflammatory Bowel Disease and Psoriasis.


    Show Resources
    You May Also Like
    SEP 10, 2020 9:00 AM PDT
    C.E. CREDITS
    SEP 10, 2020 9:00 AM PDT
    Date: September 10, 2020 Time: 9:00am (PDT), 12:00pm (EDT) Osmolality testing is relevant throughout the entire bioprocessing workflow. As customers look to refine mAb and gene therapy workf...
    NOV 18, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 18, 2020 8:00 AM PST
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    OCT 29, 2020 6:00 AM PDT
    C.E. CREDITS
    OCT 29, 2020 6:00 AM PDT
    Date: October 29, 2020 Time: 6:00am (PDT), 9:00am (EDT), Chronic inflammation can occur as a result of a combination of genetic predispositions and environmental factors. Epigenetic modifica...
    AUG 18, 2020 10:00 AM PDT
    C.E. CREDITS
    AUG 18, 2020 10:00 AM PDT
    DATE: August 18, 2020 TIME: 10:00am PT Get deeper understanding of gene expression patterns by using assays that retain spatial organization at single cell resolution! Come learn about the n...
    C.E. CREDITS
    This drug development program is designed to create a family of broad-spectrum, pan-coronaviral drugs that respectively inhibit multiple key enzymes required for viral replication. By target...
    SEP 03, 2020 9:00 AM PDT
    C.E. CREDITS
    SEP 03, 2020 9:00 AM PDT
    DATE: September 3, 2020 TIME: 09:00am PT, 12:00pm ET xxx Learning Objectives: xxx Webinars will be available for unlimited on-demand viewing after live event. LabRoots is approved as a provi...
    Loading Comments...
    Show Resources