OCT 29, 2014 3:00 PM PDT

Drug-tailored, efficacy-predictive and prognostic biomarker approaches for proper patient selection

Speaker

Abstract

Over the last decade we have witnessed tremendous advances in our understanding of the underlying molecular alterations in human cancer. This has stimulated excitement for our ability to develop effective targeted therapies and diagnostic tests based on genetic information. However, there have been only limited successes, to a great extent due to the challenges of matching inferred signaling pathway alterations based on specific genetic mutations with often inferred effects of a particular drug. The presentation will provide an example of a functional, pathway-based approach for identification of drug-tailored, efficacy-predictive biomarkers based on post-translationally modified proteins involved in the aggressive, metastatic cancer phenotype. Moreover, we will describe the de novo development and clinical validation of a novel proteomics prostate cancer biopsy test for intact tissue based on quantitative multiplex immunofluorescence and image analysis. The described approaches enable development of powerful prognostic and efficacy-predictive, protein-based, quantitative biomarkers for better clinical treatment decisions and outcome.


Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
APR 01, 2021 8:00 AM PDT
C.E. CREDITS
APR 01, 2021 8:00 AM PDT
Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
MAR 16, 2021 10:00 AM PDT
C.E. CREDITS
MAR 16, 2021 10:00 AM PDT
Date: March 16, 2021 Time: 10:00am (PST) Scientific progress and breakthroughs today are often too expensive for most institutions to acquire. Each year, the National Institutes of Health (N...
FEB 24, 2021 10:00 AM PST
C.E. CREDITS
FEB 24, 2021 10:00 AM PST
DATE: February 24, 2021 TIME: 10am PST Automated lab instruments such as liquid handlers and cell sorters are increasingly common in all types of laboratories, driving fast results for labor...
MAR 18, 2021 8:00 AM PDT
C.E. CREDITS
MAR 18, 2021 8:00 AM PDT
DATE: March 18, 2021 TIME: 8:00am PDT Sequencing of bulk cells, single cells, and nuclei is opening doors in the understanding of complex biological processes....
OCT 29, 2014 3:00 PM PDT

Drug-tailored, efficacy-predictive and prognostic biomarker approaches for proper patient selection


No demographic data is available yet for this event.


Show Resources
Loading Comments...
Show Resources