MAY 14, 2015 01:30 PM PDT

Epigenomic Profiles of Asthma

C.E. CREDITS: CE | CEU
Speakers
  • Associate Professor, Department of Medicine, University of Colorado School of Medicine, Department of Epidemiology, Colorado School of Public Health, Integrated Center for Genes, Environment,
    Biography
      I have a broad background in genomics, genetics, and bioinformatics. As a postdoctoral fellow with John Quackenbush, I identified gene expression fingerprints for molecular classification of tumors and outcome prediction in colon cancer. As an Assistant Research Professor at Duke University and then a Staff Scientist at the National Institutes of Health (NIH), I worked with David Schwartz to identify novel innate immune genes in mice by using genetic and genomic approaches. As the Deputy Director for the Center for Genes, Environment and Health, I provided oversight of next-generation sequencing, expression profiling, genotyping, and epigenomic technologies at National Jewish Health.
      My current research broadly centers on the role of genetic and epigenetic factors in complex diseases. The overarching goals of my research are to use genetics and genomics to enhance early detection, predict outcome, develop biomarkers, and design personalized therapeutic strategies in non-malignant diseases. Specific current disease areas of interest include asthma and allergy, pulmonary fibrosis, chronic beryllium disease, diabetes and obesity. Human cohorts as well as animal and cell models are used to pursue these studies.

    Abstract:

    Asthma is heritable, influenced by the environment, and is modified by in utero exposures and aging; all of these features are also common to epigenetic regulation. Furthermore, genetic variants that have been identified to date explain a small portion of asthma heritability. Finally, the transcription factors that are involved in the development of mature T cells that are critical to the Th2 immune phenotype in asthma are regulated by epigenetic mechanisms. Our group was the first to demonstrate a causal relationship between DNA methylation marks and both Th2 immunity and allergic airway disease in mice. We have also shown that DNA methylation marks in Th2 immune genes are associated with asthma and gene expression changes in peripheral blood mononuclear cells (PBMCs) from children in the inner city. We have also found pronounced changes in DNA methylation and gene expression in nasal epithelia of allergic asthmatics, suggesting that genes previously identified as important in the asthmatic airway epithelium appear to be epigenetically regulated. Our findings that epigenetic marks in immune cells and respiratory epithelia are associated with allergic asthma provide new targets for understanding the biology of the disease, developing biomarkers of exposure or disease, and potentially identifying novel therapeutic approaches for this disease. Learning Objectives 1. Discuss how epigenetic marks are influenced by the environment and are important in T cell lineage differentiation 2. Explain the association of epigenetic marks with asthma and disease subtypes


    Show Resources
    You May Also Like
    MAY 03, 2018 11:00 AM PDT
    MAY 03, 2018 11:00 AM PDT
    DATE: May 3, 2018TIME: 11:00AM PDT, 2:00PM EDTWhile stress is one of the leading causes of neuropsychiatric disorders, the molecular underpinnings of how stress induces alterations in b...
    MAY 24, 2018 09:30 AM PDT
    C.E. CREDITS
    MAY 24, 2018 09:30 AM PDT
    DATE: May 24, 2018 TIME: 9:30PM PDT The current gold standard in in vitro pre-clinical cancer treatment screening remain cell lines,...
    APR 27, 2018 10:00 AM PDT
    C.E. CREDITS
    APR 27, 2018 10:00 AM PDT
    DATE: April 27, 2018TIME: 10:00am PST, 1:00pm ESTGlioblastoma (GBM) and Medulloblastoma (MB) are the most common adult and paediatric brain tumours, both of which can have devastating c...
    MAY 22, 2018 08:00 AM PDT
    C.E. CREDITS
    MAY 22, 2018 08:00 AM PDT
    DATE: May 22, 2018TIME: 08:00AM PDT The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are closely related transcription factors that...
    AUG 15, 2018 08:00 AM PDT
    C.E. CREDITS
    AUG 15, 2018 08:00 AM PDT
    DATE: August 15, 2018TIME: 08:00AM PDT, 11:00AM EDTThe failure of current chemotherapeutic strategies in the fight against cancer can be largely attributed to the occurrence of drug res...
    JUN 29, 2018 09:00 AM PDT
    C.E. CREDITS
    JUN 29, 2018 09:00 AM PDT
    DATE: June 29, 2018TIME: 09:00AM PDT, 12:00PM EDT There is significant epidemiological evidence to suggest that the consumption of a high-broccoli diet is associated with a r...
    Loading Comments...