OCT 15, 2020 9:00 AM PDT

Evaluating the Kidney-Chip for Transporter-Mediated Drug-Drug Interactions Applications

Sponsored by: Emulate Bio
Speakers

Abstract
Date:  October 15, 2020
Time: 9:00am (PDT),  12:00pm (EDT)
 
Renal transporters play an important role in potential clinical drug-drug interactions (DDIs) as highlighted in the FDA, EMA and PMDA regulatory guidance documents. Conventionally available experimental models yield data on limited numbers of transporters in a given system. This is generally not predictive of clinical outcomes due to in vitro-in vivo discrepancies because of the interplay of multiple transporters in the proximal tubule. Since DDIs are important to clinical outcomes, with the ever increasing amount of polypharmacy there is an unmet need for a human-relevant model to study renal drug transport.
 
Covance and Emulate are collaborating to evaluate the Proximal Tubule Kidney-Chip to study transporter-mediated DDIs to fill the gap between current in vitro options and clinical trials.
 
In this webinar, scientists from Emulate and Covance will showcase promising new data on characterization of the Kidney-Chip as a model to study and predict potential drug-drug interactions. There will be three webinar speakers:
 
  • Steve Anderson PhD, CSO of Covance, will outline the need for more human-relevant cell-based to improve translation of preclinical data to the clinic and get safer, more efficacious
 
  • Kyung-Jin (KJ) Jang, Ph.D, VP of Technology Implementation & Field Science at Emulate, will highlight the Human Emulation System, an Organs-on-Chips platform that recreates the required microenvironment to enable physiologically relevant function in a human cell-based system, as a new solution to study and predict transporter-mediated DDIs
 
  • Donald McKenzie PhD, Covance’s global business lead for Drug Metabolism and Lead Optimization, will present proof-of-concept data to characterize the Proximal Tubule Kidney-Chip including efflux activities using probe substrates such as digoxin mediated by P-gp; tetraethylammonium and metformin mediated collaboratively by OCT1/2, MATE1, and MATE2-K; and para aminohippuric acid mediated by OAT1/3. The data to be presented also includes functional modulation of efflux by known inhibitors of specific transporters.
 
 
Webinars will be available for unlimited on-demand viewing after live event.
 
LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.

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