SEP 23, 2020 9:00 AM PDT

Keynote Presentation: Extracellular vesicles in Regenerative Medicine

Presented at: Cell Biology 2020
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Associate Professor of Nephrology, University of Torino, President of the Italian Society for Extracellular Vesicles - EVIta, Dept. of Molecular Biotechnology and Health Sciences
    Biography

      Prof. Benedetta Bussolati obtained her medical degree at the University of Torino (Italy) and her PhD on Physiopathology of the Renal Insufficiency at the University of Parma (Italy). She currently holds the position of Associate Professor of Nephrology at the University of Torino and director of a Research group at the Molecular Biotechnology Centre. Dr. Bussolati has extensive experience in studies of stem cell biology and regenerative medicine that include characterization of various stem cell types and their potential use for tissue regeneration. She is actually focusing on the role extracellular vesicles as therapeutic tools for modulating tissue regeneration, angiogenesis and tumor vasculogenesis. She is founder and president of the Italian Society of Extracellular Vesicles (EVIta).


    Abstract

    Extracellular vesicles (EVs) are nanosized vesicles containing active proteins, lipids, and different types of genetic material such as non coding RNA species, related to the characteristics of the originating cell. They possess a distinctive capacity to communicate over long distances. EVs have been involved in the modulation of several pathophysiological conditions and, more importantly, stem cell-derived EVs appear as a new promising therapeutic option. Convincing evidence of the regenerative potential of EVs released by stem cells and, in particular, mesenchymal stromal cells has been shown in different injury models. My presentation will focus on the potential of stem cells-EVs in acute and chronic renal injury, describing mechanisms of action and active cargo. Besides, the clinical application of stem cell-EVs will be discussed.

    Learning Objectives:

    1. Rationale of the application of Stem Cell-EVs for regeneration

    2. Role of EV cargo for Regenerative medicine

    3. EV in vivo Biodistribution

    4. Limits and promises for clinical application


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