Extracellular vesicles (EVs) are nanosized vesicles containing active proteins, lipids, and different types of genetic material such as non coding RNA species, related to the characteristics of the originating cell. They possess a distinctive capacity to communicate over long distances. EVs have been involved in the modulation of several pathophysiological conditions and, more importantly, stem cell-derived EVs appear as a new promising therapeutic option. Convincing evidence of the regenerative potential of EVs released by stem cells and, in particular, mesenchymal stromal cells has been shown in different injury models. My presentation will focus on the potential of stem cells-EVs in acute and chronic renal injury, describing mechanisms of action and active cargo. Besides, the clinical application of stem cell-EVs will be discussed.
1. Rationale of the application of Stem Cell-EVs for regeneration
2. Role of EV cargo for Regenerative medicine
3. EV in vivo Biodistribution
4. Limits and promises for clinical application