FEB 06, 2014 11:00 AM PST

Formation of Bacterial Biofilms

  • Animal facility director, Metropolitan University, Campus Xochimilco, Mexico

      Dr. Yvonne Heuze is Mexican. She has a master in science in biology of the reproduction and a PhD in Biology science and health. She is currently the animal facility director in the Metropolitan University, Campus Xochimilco in Mexico City.
      She has an specialization in laboratory animals science, with the certification of the professional exercise of the medicine and animal husbandry in laboratory animal science. Period 2006-2011 and 2012-2017 CONCERVET-SEP.
      She coordinates the technical committee for certification fo the professional exercise of the medicine and animal husbandry y laboratory animal science. Period 2013 - 2016. Professor in DVM and Master in Science degree in the Department of Agricultural and Animal Production, Division of Biological Sciences and Health at the Metropolitan University, Campus Xochimilco. Member of the Editorial Committee of the mexican magazine, Laboratory Animal Science
      She has the award of the "Merit Guild 2007. Mexican Association of the Science in Laboratory Animals A.C." For outstanding career in the field of the science of laboratory animals in Mexico and the "Medal Merit University 2012". Metropolitan University. Campus Xochimilco
      Consultant of several laboratory-animal housing in Mexico as Metropolitan University Campus Iztapalapa and Lerma, National Institute of Pediatrics, University of Villa Hermosa Tabasco and different laboratories.Projects in agreement with the company private as: Rilato Bioscience (United States), laboratorios Silanes, Bioclon. BioRad, Lapisa, Axacel, Landsteiner, Federal Commission for protection against health risks, SSA, Nacional Institute of Psychiatry, National Institute of Pediatrics.
      She has participated in the organization of 16 international congress and symposia; submitted 40 papers in international congress; 60 at national congress. 12 conferences. 50 animal science seminars, 65 indexed international journals.


    Biofilms, are defined as communities of microorganisms that grow embedded in a self-generated matrix of exopolysaccharides and adhered to an inert surface or a live tissue. They are formed 95% of water, the rest are microbial cells and their derivatives.In the first works on the biofilm structure, one of the questions that arose was how bacteria within the biofilm could have access to nutrients and oxygen. Studies demonstrated that the architecture of the biofilm matrix is not solid and has channels that allow the flow of water, nutrients and oxygen, even in the deeper layers of the biofilm. The existence of these channels does not avoid, however, that inside the biofilm can be found different environments in which the concentrations of nutrients, pH, or oxygen are different. This increases the heterogeneity of the physiological state in which the bacterium is found within the biofilm and makes difficult its study for it gives it a higher resistance. The stages for biofilm formation are: 1. Adhesion; 2. Extracellular matrix synthesis: grouping by chemical self-inducing signals (quorum sensing) and secretion of exopolysacharides to form the biofilm matrix; 3. Maturation and dispersion is the way of colonizing new sites. which can be transferred by water, environmental contamination, or fomites. The bacterial growth on the walls of the pipes is a very common habitat for potentially pathogenic bacteria. The presence of microorganisms in drinking water and the formation of biofilms in the distribution water systems produce bacteriological contamination and these associations may occur among bacteria, fungi, and protozoa, granting a higher resistance and pathogenesis to the biofilm. The Journal of Public Health of Mexico (2011), and the National Institute of Health, USA (2003) published that in 75% to 80% of bacterial diseases infectious, biofilm intervene.

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