APR 08, 2021 5:00 PM CEST

Generating multi-omics atlas of CD8+ T cell exhaustion vs. dysfunctional states in immuno-oncology

Sponsored by: Miltenyi Biotec
C.E. Credits: P.A.C.E. CE Florida CE
Speakers

Abstract

DATE:  April 08, 2021

TIME:  5:00pm CEST

 

THIS WEBINAR WILL BE AVAILABLE FOR ON-DEMAND VIEWING AT A LATER DATE.

 

Multi-omics involves the use of different data modalities to study multiple “omes”, such as the genome, transcriptome, epigenome, and/or the proteome, allowing an integrative approach to address complex biological enigmas. In the context of immuno-oncology, this approach enables better characterization of anti-tumor immune responses and identification of biomarkers to help tailor immunotherapeutic strategies. The success and reliability of such analyses rely on the quality of the samples. In this webinar, Miltenyi Biotec will explain how to efficiently prepare cells for genomic analysis that can be applied to other “-omic” analysis, with a special focus on the preparation of cells from tumors.

 

Prof. Abhishek Garg from KU Leuven has years of experience studying cancer immunology and immunotherapy. Recently he led a multi-partner collaborative investigation on chronically-sensitized states of tumor-infiltrating CD8+ T cells, broadly classifying them as immunotherapy-responsive differentially exhausted, or immunotherapy-resistant severely dysfunctional. Prof. Garg will present in this webinar how they have conducted an orthogonal multi-omics exploration of exhausted/dysfunctional CD8+ T cells across existing and in-house cancer patient cohorts (>4000 patients across different human cancers). This study comprehensively expands clinical knowledge on CD8+ T cell- states, and provides crucial computational/technical resources to guide the design of future T cell-targeting immunotherapy clinical trials.

 

Learning Objectives:

  • Learn which steps are important in the preparation of cells prior to genomic analysis, and how to apply these steps to efficiently prepare cells from tumors for high quality and reliable genomic analysis.

  • Interpret the concept of CD8+ T cell exhaustion/dysfunction as a “continuum of differential states” rather than a definitive state.

  • Decipher the importance of balanced biomarker approaches for identifying precise clinical CD8+ T cell states, to correctly guide clinical application of immunotherapies and tailor it to appropriate cancer-type/patients.

 

 


 
LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
JUL 15, 2021 9:00 AM PDT
JUL 15, 2021 9:00 AM PDT
Date: July 15, 2021 Time: 9:00am (PDT), 12:00pm (EDT) The Pisces workflow robust, easy-to-use, end-to-end multi-omics solution for highly multiplexed targeted Spatial RNA analysis. VeranomeB...
MAY 18, 2021 8:00 AM PDT
C.E. CREDITS
MAY 18, 2021 8:00 AM PDT
Date: May 18, 2021 Time: 8:00am (PST) The global pandemic has caused an increased focus and scrutiny on molecular diagnostic assay development, resulting in a need for assays that provide qu...
MAY 25, 2021 8:00 AM PDT
C.E. CREDITS
MAY 25, 2021 8:00 AM PDT
Date: May 25, 2021 Time: 8:00am (PDT) Reliable expression of recombinant proteins in human, CHO, or insect cells is essential for many aspects of biomedical research and drug development, bu...
Loading Comments...
Show Resources