In 1999, she began her postdoctoral research at the department of Prof. Dr. Lehrach at the Max Planck Institute for molecular genetics and there she became head of the research group "Cardiovascular Genetics" in 2001. She holds a habilitation in molecular biology and bioinformatics. In 2011, she was honored with a Heisenberg Professorship and became full professor for Cardiovascular Genetics at the Medical Faculty of the Charité in Berlin. She is co-opted professor at the Faculty of Biology, Chemistry and Pharmacy of the Freie Universität Berlin. She leads an interdisciplinary research group (molecular biology and bioinformatics) at the ECRC. As guest scientist, she continues to collaborate with the Max Planck Institute for Molecular Genetics.
Her research activities focus on understanding the molecular basis of human cardiovascular disorders, in particular congenital heart malformations and cardiac dysfunction. Using systems biology approaches, she studies cardiac (dys)development and muscle maturation in human and mice. She investigates a broader range of disease-associated genes and epigenetic modulators in the genomic, transcriptomic, and proteomic contexts. She hopes to combine knowledge of molecular etiologies and mechanisms to eventually improve preventive and therapeutic opportunities for patients.
She is principal investigator and co-coordinator of various European efforts (HeartRepair, CardioGeNet, and CardioNeT) and principal investigator of the Berlin Institute of Health (BIH). She was a board member of the European Society of Human Genetics and is Fellow of the European Society of Cardiology (ESC) as well as a board member of the ESC Working Group on Development, Anatomy and Pathology.