OCT 01, 2019 10:00 AM PDT

High-throughput genotoxicity assays for DNA damage and mode of action analyses

Sponsored by: Miltenyi Biotec
C.E. Credits: P.A.C.E. CE Florida CE
Speakers
  • Director of Clinical Studies Litron Laboratories - Rochester, New York
    Biography
      Dr. Jeffrey Bemis received his PhD in Environmental Health and Toxicology from the University at Albany School of Public Health in Albany, NY. His thesis focused on the effects of combined exposure to the environmental contaminants polychlorinated biphenyls (PCBs) and methyl mercury on central neurotransmitter systems. Jeff then spent three years as a Postdoctoral Fellow in the Department of Environmental Medicine at the University of Rochester School of Medicine and Dentistry in Rochester, NY. Here he investigated molecular and development aspects of exposure to PCBs and dioxin using a transgenic reporter mouse model.

      Jeff began his work in genetic toxicology when he joined Litron Laboratories in 2006 as a research scientist and is now Director of Clinical Studies. In his current position Jeff serves as principal investigator for internal research efforts, study director for sponsor-supported studies and also manages clinical investigations for clients. Jeff regularly presents at national and international meetings and is an author on over 60 peer-reviewed journal articles and book chapters. Jeff has been an active member of the Society of Toxicology for over eighteen years. He has served on the Education, Student and New Investigator Affairs committee of the Environmental Mutagen and Genomics Society for four years, and is its currently Co-Chair as well as a Council Member for EMGS, and is the representative of the New Technology Special Interest Group on the Program Committee. Jeff was also on the Board of Directors for the Genetic Toxicology Association. He served for three years on the Program Committee for the annual meeting and chaired it for the last two years. Jeff recently served as an expert working group member of the In Vitro Mammalian Gene Mutation Assays Workgroup of the International Workshops on Genotoxicity Testing.
    • Product Manager Flow Cytometry Instruments - Miltenyi Biotec
      Biography
        Jakob Bonse completed his PhD at the Westfälische Wilhelms University of Münster, where he worked in the field of Molecular Nephrology, Metabolism, and End-Stage Renal Diseases. Jakob gained expert knowledge in the field of Hippo Signaling and Cell Transduction. He joined the Marketing team of Miltenyi Biotec in June 2019 as a product manager, where he is responsible for flow cytometry instruments and is co-ordinating dedicated marketing activities.

      Abstract

      DATE: October 1, 2019
      TIME: 10:00am PDT

      The toxicological testing market is no stranger to the principle of the three Rs of research: replacement, reduction, and refinement. With that to guide us, we will review ways to fulfill these requirements in the context of genetic toxicology testing, and as applicable to the drug development and discovery processes.

      In this presentation, Miltenyi Biotec and Litron Laboratories will review semi-automated products and procedures. These combine instrumentation and kits for in vitro micronucleus assessment and additional flow cytometry-based kits for evaluating multiple endpoints of DNA damage response pathways. In this we deliver comprehensive information about the status of a potential compound and its mode of action. Simultaneously, the use of in vitro assays, miniaturization with plate-based set up, and multi-endpoint assays deliver content-rich analyses whilst keeping to the three Rs.

      Learning Objectives:

      • Understand current in vitro approaches to genotoxicity assessment
      • Ensuring optimal data acquisition with automated and standardized Express Modes
      • Fulfillment of the three Rs of research in the context of genetic toxicology testing
      • Review benefits of high throughput/high content sample analysis 

       

      Webinars will be available for unlimited on-demand viewing after live event.

       

      LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


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