SEP 09, 2020 9:00 AM PDT

Keynote Presentation: Human Monoclonal Antibodies for Emerging Agents

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Director, Vanderbilt Vaccine Center
    Biography

      Dr. James Crowe is Director of the Vanderbilt Vaccine Center and the Ann Scott Carell Professor of Pediatrics, Pathology, Microbiology and Immunology at Vanderbilt. His laboratory studies the human immune response to infection for a wide variety of major human pathogens, including many emerging infections. His research group uses a very broad array of techniques including molecular and cellular biology, single-cell biology and synthetic genomics, state-of-the-art imaging and flow cytometry, bioinformatics, and bioengineering approaches to attack scientific problems at the forefront of immunity research. The group has been recognized widely as a leader in antibody sciences, for instance as the Best Academic Research Team, 11th Annual Vaccine Industry Excellence Awards, World Vaccine Congress, recipient of the 2019 Merck Future Insight Prize for Pandemic Preparedness, and large-scale research grants and contracts from NIH and DoD, including the DARPA Pandemic Prevention Program (P3).


    Abstract

    Epidemics are occurring at an increasing pace and scale. Our laboratory group has developed platform technologies for discovery of broad and potent neutralizing antibodies for many emerging infectious diseases. Studying diverse pathogens, we have discovered general principles about the genetic, molecular, and structural basis for virus neutralization by human antibodies. I will discuss mechanisms of neutralization and review specific case studies of antibiotic discovery programs for emerging infections leading to therapeutic drug candidates now in the clinic.

    Learning Objectives:

    1. Explain the concepts of sites of vulnerability for antibody-mediated neutralization

    2. Define 3 common mechanisms of virus neutralization

    3. Explain the rationale for rational selection of antibody combinations


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