Human Tissue models for better therapies

C.E. Credits: P.A.C.E. CE Florida CE
Speakers
  • Chief Technology Officer, Mimetas -The Organ on a Chip Company
    Biography
      Bas Trietsch is the CTO and co-founder of MIMETAS. He is co-inventor of the OrganoPlate, optimized it towards a mass manufacturable product and enabled establishment of Mimetas' production facility. He developed the initial tissue models on the OrganoPlate and continues to support model and assay development in the OrganoPlate®. As Chief Technology Officer he currently drives the continued innovation and development of the OrganoPlate, related equipment and cell based products. Bas holds a PhD in biopharmaceutical sciences from Leiden University and co-authored over 40 peer reviewed publications and patents.

    Abstract:

    The OrganoPlate is a microtiterplate based Organ-on-a-Chip platform for high throughput drug safety and efficacy screening. It contains up to 96 cell culture  chambers that allow co-culture of 3D tissues under continuous perfusion. Highly physiologically relevant tissue and disease models are constructed by (co-)culturing human cells in 3D under continuous perfusion whilst maintaining ease of use and compatibility with standard equipment. This presentation will highlight several applications of the OrganoPlate including models of vasculature, gut, kidney, liver, brain and tumor physiology including iPS and organoid based tissues. The models are interrogated using a variety of assays including (Confocal) Immunocytochemistry, calcium imaging, barrier integrity assessment, qPCR and TEER measurements.

    Learning Objectives:

    1. Introduce the audience to the fields of organ-on-a-chip and micro physiological systems for preclinical research

    2. Explain current tissue culture modalities and (high throughput) assays available in organs on chips


    Show Resources
    You May Also Like
    OCT 02, 2019 11:00 AM PDT
    OCT 02, 2019 11:00 AM PDT
    DATE: October 2, 2019TIME: 11:00am PDT, 2:00pm EDT Ditch the Excel spreadsheets and manage your molecular workflows entirely in your LIMS Achieve configuration of molecular workf...
    JAN 23, 2020 9:00 AM PST
    C.E. CREDITS
    JAN 23, 2020 9:00 AM PST
    DATE: January 23, 2020 TIME: 9:00am PST, 12:00pm EST...
    SEP 05, 2019 4:00 PM CEST
    C.E. CREDITS
    SEP 05, 2019 4:00 PM CEST
    DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
    NOV 18, 2019 7:00 AM PST
    C.E. CREDITS
    NOV 18, 2019 7:00 AM PST
    DATE: November 18, 2019TIME: 7:00am PST, 11:00am EST, 4:00pm CEWT How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop th...
    FEB 26, 2020 9:00 AM PST
    C.E. CREDITS
    FEB 26, 2020 9:00 AM PST
    DATE: February 26, 2020 TIME: 9:00am PST 3D cell culture and analysis and the study of organoids and spheroids are becoming more prevalent as a research method in publications as traditional...
    MAR 03, 2020 9:00 AM JST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    MAR 03, 2020 9:00 AM JST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: March 3, 2020 TIME: 9:00am JST A major limitation in the ex vivo expansion of harvested human hematopoietic stem-progenitor cells (HSPCs) is the rapid differentiation of HSPCs at the e...
    Loading Comments...
    Show Resources