OCT 10, 2018 06:00 AM PDT
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Immunogenic Cell Death in Cancer: The Quantity/Quality Conundrum

  • Assistant Professor, Weill Cornell Medical College/New York Presbyterian
      Lorenzo Galluzzi (born 1980) is currently Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College (New York, USA), and Honorary Associate Professor at the Faculty of Medicine of the Paris Descartes University (Paris, France).

      Prior to joining Weill Cornell Medical College (2017), Lorenzo Galluzzi was a Junior Scientist of the Research Team "Apoptosis, Cancer and Immunity" at the Cordeliers Research Center (Paris, France; 2012-2016). Lorenzo Galluzzi did his post-doctoral training at the Gustave Roussy Cancer Center (Villejuif, France; 2009-2011), after receiving his PhD from the Paris Sud University (Le Kremlin-Bicetre, France; 2005-2008). He is also Associate Director of the European Academy for Tumor Immunology (EATI), and Founding Member of the European Research Institute for Integrated Cellular Pathology (ERI-ICP).

      Lorenzo Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. In particular, he provided profound insights into the links between adaptive stress responses in cancer cells and the activation of a clinically relevant tumor-targeting immune response in the context of chemotherapy and radiation therapy. Lorenzo Galluzzi has published more than 350 scientific articles in international peer-reviewed journals. According to a survey published by Lab Times, he is currently the 6th and the youngest of the 30 most-cited European cell biologists (relative to the period 2007-2013).

      Lorenzo Galluzzi currently operates as Editor-in-Chief of three journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, and Molecular and Cellular Oncology (which he co-founded in 2013). In addition, Lorenzo Galluzzi currently serves as Section Chief Editor for Oncotarget (Autophagy and Cell Death section), Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease.


    Mammalian cells including cancer cells respond to stress with mechanisms that promote the preservation of cellular functions. These mechanisms have been intensively investigated as potential targets to boost the cytotoxicity of cancer therapy. However, the same pathways underlie the emission of signals that coordinate adaptive responses across tissues, organs and the whole organism, implying that their inhibition may compromise immunological tumour control. Thus, the quantity of cancer cells that succumb treatment (which never is 100%) may be less important than the actual mechanisms activated in the course of cancer cell death for disease outcome.

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