FEB 08, 2017 6:00 AM PST

Impact of Two Formulations of Buprenorphine on Postsurgical Condition in Mice

Speaker
  • Veterinarian, Columbia University Medical Center
    Biography
      Dr. Herndon obtained her Doctorate of Veterinary Medicine from Oregon State University, where she spent time at the Oregon National Primate Center, including working in a Huntington's Disease research laboratory. Following completion of veterinary school, Dr. Herndon began a three year post-doctoral research residency for veterinary laboratory animal medicine at Columbia University. While in this role, Dr. Herndon oversees the general animal care in the facilities, trains investigators on aseptic technique and surgical skills in rodent models, performs veterinary protocol review consultations, is an active participant in IACUC meetings, has participated in site visits from the USDA, Department of Health, and AAALAC, and assists with the anesthesia monitoring of USDA regulated species. She completed a research project comparing mortality rates, selected inflammatory cytokines, and overall condition of mice administered buprenorphine SR to buprenorphine HCL in a murine model of polymicrobial sepsis, the results of which were published in Journal of Comparative Medicine, December 2016. She will complete her residency June 2017.

    Abstract

    DATE: February 8, 2017
    TIME: 6:00am PT, 9:00 ET

    Several regulatory bodies require that animals used in biomedical and behavioral research exposed to procedures that may cause more than momentary or slight pain or distress should be provided with appropriate sedation, analgesia, or anesthesia. However, use of analgesics in certain murine models is a topic of debate, as analgesics have the potential to have an effect on biological responses of an animal.  A common analgesic used in research is the synthetic opiate buprenorphine HCL. Sustained release Buprenorphine (Bup SR) is a sustained-release injectable formulation of buprenorphine that has grown in popularity due to its extended duration of action compared to standard buprenorphine. This presentation will explore the findings of several research reports comparing buprenorphine HCL to sustained release formulations of buprenorphine with regards to effects on experimental data and postsurgical condition in mice.

    Learning Objectives:

    • Identify the benefits and disadvantages of the use of buprenorphine (HCL and sustained release) analgesia in a murine model
    • Describe methods to evaluate postsurgical condition in mice

    Show Resources
    You May Also Like
    JAN 23, 2020 9:00 AM PST
    C.E. CREDITS
    JAN 23, 2020 9:00 AM PST
    DATE: January 23, 2020 TIME: 9:00am PST, 12:00pm EST...
    APR 07, 2020 8:00 AM PDT
    C.E. CREDITS
    APR 07, 2020 8:00 AM PDT
    DATE: April 7, 2020 TIME: 8:00am PT, 11:00am ET This webinar sets out to establish why quality control is key to robust, reliable, reproducible science. We will look at best practice criteri...
    FEB 26, 2020 9:00 AM PST
    C.E. CREDITS
    FEB 26, 2020 9:00 AM PST
    DATE: February 26, 2020 TIME: 9:00am PST 3D cell culture and analysis and the study of organoids and spheroids are becoming more prevalent as a research method in publications as traditional...
    MAY 08, 2020 10:00 AM PDT
    C.E. CREDITS
    MAY 08, 2020 10:00 AM PDT
    DATE: May 8, 2020 TIME: 10:00am PT, 11:00am MT, 1:00pm ET The application of next generation sequencing to interrogate immune repertoires and methods in which these highly complex dataset...
    JUN 09, 2020 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    JUN 09, 2020 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: June 9, 2020 TIME: 10:00am PT, 1:00pm ET The presentation will first discuss sepsis as a disease and then explain the importance of performing diagnostic tests in the clinical labora...
    APR 30, 2020 4:00 PM CEST
    C.E. CREDITS
    APR 30, 2020 4:00 PM CEST
    DATE: April 30, 2020 TIME: 7am PT, 10am ET, 4pm CEST Aged more than one century, nucleic acid purification is anything but ordinary. Nucleic Acid Purification, also termed Nucleic Acid Extra...
    Loading Comments...
    Show Resources
    Attendees
    • See more