His research has focused on new indications in stereotactic radiosurgery, the search for surgical treatments for drug-resistant neurological diseases, particularly in intracerebral infusion of anticonvulsant drugs, neurostimulation and cell therapy applied to neurological diseases.
His research projects include the regeneration of the nigrostriatal pathway with biomaterials in Parkinson disease models, the use of biomaterials for the repair of the cerebral cortex, the definition of targets for deep brain stimulation using brain connectomics and the induction of brain plasticity. He has been project leader of several international and national competitive funds and he is currentnly leading six clinical trials on brain stimulation and stem cells for stroke. He has supervised 15 doctoral theses and has published more than 100 research papers in clinical and applied neurosciences. He has served as chairman of the research committee of the EANS and is member of the boards of the ESSFN and WSSFN.