MAR 13, 2019 12:00 PM PDT

Innovative Neurotechnologies: Early Feasibility Study of a Visual Cortical Prosthesis for the Blind: The Orion Visual Prosthesis System

Presented at: Neuroscience 2019
Speaker
  • Professor of Neurosurgery and Radiation Oncology and affiliated faculty in Bioengineering and Neuroscience, UCLA Medical Center & UCLA Brain Research Institute
    BIOGRAPHY

Abstract

Stimulation of human visual cortex is known to elicit visual perceptions that could potentially be used for restoring artificial vision to individuals who have lost their vision due to non-cortical etiologies. Although there have been attempts to build brain stimulators for the visual cortex in the past, fully implanted, chronic cortical visual prostheses have remained theoretical until recently. The Orion Visual Cortical Prosthesis System, which is currently being tested in a clinical trial, is a new device that is intended to restore some functional vision to blind patients.

This is a five-year, prospective, non-randomized, single-arm early feasibility study (clinicaltrials.gov NCT03344848) of subjects who are bilaterally blind with bare light or no light perception due to non-cortical etiology. The main objectives are to evaluate the safety of placing and activating an electrode array on the medial surface of the occipital lobe in blind patients; to evaluate the functionality of the device; to perform research to study the nature of the vision provided by the Orion; and to obtain input for future device design. There are five subjects between two study centers.

The Orion System comprises an implant (consisting of an electronics package, receiving antenna, and an electrode array with 60 non-penetrating electrodes); glasses with a video camera; headwear containing a transmitting antenna; and a video processing unit (VPU). The video camera collects real-time visual information, which is then processed by the VPU and converted to stimulation patterns on the electrode array. A radio frequency link between the transmitting and receiving antenna sends data and power to the implant.
Four subjects have been implanted at UCLA, three males and one female. As of January 30, 2019, average implant duration was 9.8 months. Average age at time of implant was 50.3 years. Cause of blindness included trauma (burn), trauma (car accident), infection, and pediatric glaucoma. All subjects had bare or no light perception at the time of implant, but were previously sighted.
All subjects reports seeing phosphenes with stimulation through virtually all electrodes implanted. Stimulation parameters are within expected ranges and generally stable over time. Despite similar implant techniques, spatial maps vary by subject but are generally stable within subjects. The field of view is larger than that seen with retinal prosthetics. Early testing with light localization and direction of motion testing reveal the ability to detect motion in most subjects. Real world use has shown the ability to use the device to navigate the environment. One serious adverse event of seizure has been noted. Future work will focus on maximizing stimulation parameters and working with visual rehabilitation specialists to maximize utility.


Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
SEP 17, 2021 12:00 PM CST
C.E. CREDITS
SEP 17, 2021 12:00 PM CST
Date: September 16, 2021 Time: 9:00pm (PDT), 12:00am (EDT) 3D cellular models like organoids and spheroids offer an opportunity to better understand complex biology in a physiologically rele...
OCT 27, 2021 6:00 AM PDT
C.E. CREDITS
OCT 27, 2021 6:00 AM PDT
Date: October 27, 2021 Time: 6:00 AM PDT, 9:00 AM EDT Etanercept is a recombinant Fc fusion protein therapeutic that has a complex distribution of post-translation modifications (PTM), such...
OCT 20, 2021 10:00 AM PDT
C.E. CREDITS
OCT 20, 2021 10:00 AM PDT
Date: October 20, 2021 Time:10:00am (PDT), 1:00pm (EDT) As the prevalence of Diabetes continues to rise in many areas across the globe, healthcare providers continue to look for methods that...
MAR 13, 2019 12:00 PM PDT

Innovative Neurotechnologies: Early Feasibility Study of a Visual Cortical Prosthesis for the Blind: The Orion Visual Prosthesis System

Presented at: Neuroscience 2019

Specialty

Brain

Brain-Computer Interface

Geography

North America50%

Registration Source

Website Visitors100%

Job Title

Student50%

Post Doc50%

Organization

Academic Institution50%

Other50%


Show Resources
Loading Comments...
Show Resources