FEB 14, 2019 10:30 AM PST

Integrating In Vitro Microtissues and In Vivo endpoints in Drug Discovery & Development

C.E. Credits: RACE
Speaker
  • Associate Director of Mechanistic and Investigative Toxicology, Takeda Pharmaceuticals
    Biography
      Matt Wagoner leads the Global Investigatory Toxicology network for Takeda Pharmaceuticals, where their team applys microphysiological systems (MPS) as predictive and mechanistic toxicology tools in support of discovery-phase projects. Before Takeda, Matt led the mRNA safety strategy for AstraZeneca Pharmaceuticals, and worked to develop and deploy MPS tools in support of projects. Matt has his PhD in Molecular and Cellular Pharmacology from the University of Wisconsin-Madison and bachelors in biochemistry from the University of Illinois Urbana Champaign.

    Abstract

    This presentation will discuss and review the promise and potential of 3D Microtissues, and the challenges of using these Microtissues as Hazard ID tools. Lastly, we will discuss the potential application of Neural Microtissues in drug discovery screening. 

    Learning Objectives: 

    1. Understanding the strengths and limitations of in vitro and in vivo assays for hazard identification and risk assessment.  
    2. Examining how 3D Microtissues can improve hazard identification in drug discovery, and de-risking during drug development.  


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