NOV 09, 2017 7:30 AM PST

Keynote Presentation: Integration of the Simplexa C. difficile Direct assay into a two-step algorithm for the laboratory diagnosis of C. difficile

Speaker
  • Professor of Pathology and Laboratory Medicine, University of Louisville - Medical Director of the Clinical Microbiology & Molecular Diagnostics Laboratory, University of Louisville Hospital
    Biography

      Dr. Snyder is currently the Director of Microbiology and Infectious Disease Molecular Diagnostics at the University of Louisville Hospital, Louisville, KY. He holds the academic title of Professor in the Department of Pathology and Laboratory Medicine. He is board certified in Medical Microbiology and Public Health by the American Academy of Microbiology and was elected to Fellowship in the Academy in 1989.

      Prior to joining the University of Louisville School of Medicine, Dr. Snyder served as the Director of Microbiology at the Norton-Kosair Children’s Hospital (1977-1986) and the Veteran’s Administration Medical Center in Louisville (1973-1977).

      Dr. Snyder has over 35 years of experience in the field of clinical microbiology and has authored or co-authored over 70 papers in the peer reviewed literature, has 10 book chapters to his credit, and has presented numerous research posters in addition to being a frequent invited speaker. He holds professional memberships in the American Society for Microbiology, South Central Association for Clinical Microbiology, and the Infectious Disease Society of America. He currently serves on several editorial boards including the Journal of Clinical Microbiology, Journal of Surgical Infections, and Diagnostic Microbiology and Infectious Diseases. 

      Dr. Snyder led the development of the ASM Sentinel Level Laboratory Guidelines for BioThreat Agents. His most recent contribution was as the Senior Author of a Systematic Review and Meta Analysis for the Laboratory Detection of Clostrioides difficile. Dr. Snyder served 43 years in the Army Reserves, and commanded the Medical Task Force in Iraq in 2011; and retired, at the rank of Colonel, in September 2012.


    Abstract

    Clostridium difficile infection (CDI) has become the leading cause of healthcare associated infections in the United States and currently accounts for 15% to 20% of infectious diarrhea in the healthcare setting.  Accurate diagnosis of CDI is criticalin promoting effective management of patients and implementing appropriate infection control measures to disrupt and prevent transmission.  Reliable diagnostic tests are needed to confirm or negative a presumptive clinical diagnosis of CDI.  Nucleic acid amplification tests (NAAT) have become available within the last ten years and have been used in one of two ways: 1) Direct testing, 2) algorithmic testing as a supplement to enzyme immunoassay (EIA) for the detection of glutamate dehydrogenase and Toxin A/B.  Much controversy exists as to which approach, direct NAAT or algorimthic is optimal for the laboratory diagnosis of CDI.  The latest NAAT-based test to enter the market is the Simplexa C. diffcile Direct Assay,   An evaluation of this technology was conducted for the purpose of determining its overall performance and potential integration into two-step algorithm testing format.  The assay was evaluated and compared to two other NAAT platforms.  The results of this evaluation are the subject of this presentation.


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