FEB 13, 2019 7:30 AM PST

Keynote Presentation: Modernizing Drug Development Through Digital Transformation and Non-Traditional Models

C.E. Credits: RACE
Speaker
  • Head of Emerging Technologies, LAS, Novartis
    Biography
      Szczepan Baran, VMD, MS is the Head of Emerging Technologies at Novartis Institutes for Biomedical Research. In this position, he leads global strategic initiatives focused on digital efforts to uncover new scientific insights, generate scientific breakthroughs and collect more physiologically and clinically relevant data & endpoints to optimize reproducibility and clinical translation.

      He has held multiple faculty and startup positions and has served on multiple boards. Currently he is serving as Board Member of North America 3Rs Collaborative and is a Chair of the 3Rs Working Group International Consortium for Innovation & Quality in Pharmaceutical Development. Witin the IQ he leads Digital Vivarium Scoping and Animal Studies Modernization Working Groups.

      Dr. Baran is a graduate of the University of Delaware and the University Of Pennsylvania School of Veterinary Medicine. He completed a residency in Laboratory Animal Medicine and a Masters of Science in Comparative Medicine at the University Of Washington School Of Medicine.

    Abstract

    Digitalization has transformed virtually every industry, but it has been slow to gain traction within the preclinical phase of the drug development journey. Recent advances in digital vivarium technologies present opportunities to improve study precision, data management, monitoring and extraction from animal studies. Engaging in non-traditional models in vitro (such as organ-on-chip) and in vivo in companion animals has the potential to positively impact the preclinical phase of drug development. 

    These novel models and digital technologies could enhance the reproducibility and clinical relevance of preclinical studies, increase the sensitivity for detecting pharmacologically or toxicologically significant changes, accelerate the development of novel anti-cancer therapies and even yield animal welfare benefits. These capabilities could add significant value to our current approaches to drug development animal studies. 

    Learning Objectives: 

    1. Overview of emerging vivarium technologies
    2. Organ-on-chip systems primer
    3. Introduction to the field of comparative oncology


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