JUN 20, 2018 7:30 AM PDT

Keynote Presentation: Supporting Precision Medicine and Clinical Research at Scale - Challenges and Opportunities

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Senior Director of Translational Genomics and Product Development, Institute Scientist, Broad Institute of MIT and Harvard
    Biography
      Niall J. Lennon, PhD, is Senior Director of Translational Genomics and Product Development with the Genomics Platform at the Broad Institute of MIT & Harvard. Niall has been working on NGS applications and technology development at the Broad for over 11 years. Most recently, Dr. Lennon oversaw the creation, certification and launch of a CLIA certified & CAP accredited laboratory within the Broad. He led the efforts to validate and implement a clinical Whole Exome sequencing test for both germline and somatic samples.
      Niall is currently an Adjunct Assistant Professor of Biomedical Engineering at Tufts University. Niall has received a Black Belt in Six Sigma for his work on process design and optimization. He also holds an executive certificate in Management and Leadership from the MIT Sloan School of Management. Niall earned a PhD in Pharmacology, and a BSc from University College Dublin, Ireland.

    Abstract

    Precision medicine based on molecular profiling is moving from the realm of clinical utility studies towards standard of care. There remain, however, significant technological and implementation challenges that need to be addressed to ensure the widespread access to high complexity tests. These challenges include the provision of high quality, scalable assays that can be offered in clinically meaningful timeframes and at a cost that does not limit adoption. In addition, the computational and analytical environments must exist to host, compute, and deliver the increasingly large data sets created for each patient. There needs to be agreement on best practices and specifications for performance of secondary analysis tools (variant callers) across all classes of clinically meaningful variant categories. And, there needs to be education and training of a large network of variant review scientists, clinical geneticists, and molecular pathologists on variant interpretation and classification. This presentation will contemplate these challenges, highlight areas where progress has been made, and where more has yet to be done. 


    Show Resources
    You May Also Like
    JAN 23, 2020 9:00 AM PST
    C.E. CREDITS
    JAN 23, 2020 9:00 AM PST
    DATE: January 23, 2020 TIME: 9:00am PST, 12:00pm EST...
    APR 07, 2020 8:00 AM PDT
    C.E. CREDITS
    APR 07, 2020 8:00 AM PDT
    DATE: April 7, 2020 TIME: 8:00am PT, 11:00am ET This webinar sets out to establish why quality control is key to robust, reliable, reproducible science. We will look at best practice criteri...
    FEB 26, 2020 9:00 AM PST
    C.E. CREDITS
    FEB 26, 2020 9:00 AM PST
    DATE: February 26, 2020 TIME: 9:00am PST 3D cell culture and analysis and the study of organoids and spheroids are becoming more prevalent as a research method in publications as traditional...
    MAY 08, 2020 10:00 AM PDT
    C.E. CREDITS
    MAY 08, 2020 10:00 AM PDT
    DATE: May 8, 2020 TIME: 10:00am PT, 11:00am MT, 1:00pm ET The application of next generation sequencing to interrogate immune repertoires and methods in which these highly complex dataset...
    JUN 23, 2020 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    JUN 23, 2020 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: June 23, 2020 TIME: 10:00am PT Human mesenchymal stromal or stem cells (MSCs)-based immunomodulation treatment has been proposed as a suitable therapeutic approach for many diseases, s...
    MAR 03, 2020 9:00 AM JST
    C.E. CREDITS
    MAR 03, 2020 9:00 AM JST
    DATE: March 3, 2020 TIME: 9:00am JST A major limitation in the ex vivo expansion of harvested human hematopoietic stem-progenitor cells (HSPCs) is the rapid differentiation of HSPCs at the e...
    Loading Comments...
    Show Resources