Genomics and metagenomics have become ubiquitous research efforts.  Here we will show details of the development of physical, computational, and even space-based standards for metagenomics, as part of the International Metagenomics and Microbiome Standards Alliance (IMMSA).  Also, pilot data will be shown for enabling patients to become more involved in their ‘omics data, including an integrative genomics view of entire cities (based on our MetaSUB project) that leverages longitudinal metagenome and microbiome profiles of the world’s subway systems and cites, including the 2016 Rio Olympics. All of these methods and molecular tools work together to guide the most comprehensive, longitudinal, mutli-omic view of integrated genomics with the NASA Twins Study and new technologies to mine, engineer, and sequence DNA in for long-term human space travel.