SEP 12, 2018 1:30 PM PDT

The NCTC 3000 Project: Mapping the Genetic Codes of 3000 Pathogenic Bacteria

Speaker
  • Head of Culture Collections, National Infection Service, Public Health England (PHE)
    Biography
      Julie joined the UK's Public Health Laboratory Service in 1990 after working for a few years in clinical diagnostic microbiology laboratories within the National Health Service. Initially she developed and organised proficiency testing schemes for food microbiology, then later her role expanded to include water microbiology. Organisational change meant that she now works for Public Health England and from 2012 has been the Head of Culture Collections, a biological resource centre with global reach. She studied for her first degree in Manchester, higher degree at the University of Surrey and has particular interest in the preservation of bacteria and in scientific communication.

    Abstract

    Reducing the impact of infectious diseases is becoming increasingly vital as the prevalence of antimicrobial resistance (AMR) continues to rise, threatening the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses and fungi. The evolution of “superbugs” that can evade one or multiple drugs is one of the biggest threats facing medicine today. 

    At the beginning of the 20th century a forward-thinking UK microbiologist, Dr Sir John Ledingham, recognised a need for a trustworthy source of globally-available authentic bacteria for scientific studies and went on to establish the National Collection of Type Cultures (NCTC) in 1920. This collection of live clinically-significant bacteria, encompassing strains isolated during the 19th century alongside those from the present day, represents a history of bacterial pathogens that cannot be replicated in a modern post-antibiotic environment. 

    By using long read whole genome sequencing technology, the team responsible for curating and operating NCTC collaborated with molecular scientists at the Wellcome Sanger Institute in decoding the DNA of more than 3000 reference strains of pathogenic bacteria, many of which cause deadly diseases such as plague, dysentery, cholera and tuberculosis. This project has provided genomic data that researchers will be able to use to better understand these diseases and how they become resistant to antibiotics. The publicly available genomic maps support the development of new diagnostic tests, vaccines and treatments.
     

    Learning Objectives: 

    1. Understand the value of a culture collection in biomedical research
    2. Recognise the significance of historical strains in understanding microbial evolution
    3. Recognise some of the benefits of long read sequencing techniques for delivering reference genomes for pathogenic bacteria 


    Show Resources
    You May Also Like
    DEC 02, 2020 8:00 AM PST
    C.E. CREDITS
    DEC 02, 2020 8:00 AM PST
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    OCT 08, 2020 7:00 AM PDT
    C.E. CREDITS
    OCT 08, 2020 7:00 AM PDT
    DATE: October 8, 2020 TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop thinking about ho...
    SEP 10, 2020 9:00 AM PDT
    C.E. CREDITS
    SEP 10, 2020 9:00 AM PDT
    Date: September 10, 2020 Time: 9:00am (PDT), 12:00pm (EDT) Osmolality testing is relevant throughout the entire bioprocessing workflow. As customers look to refine mAb and gene therapy workf...
    AUG 25, 2020 8:00 AM PDT
    C.E. CREDITS
    AUG 25, 2020 8:00 AM PDT
    DATE: August 25, 2020 TIME: 8:00am PDT, 10:00am CDT, 11:00am EDT Recombinant lentivirus (LV) and adeno-associated virus (AAV) are critical components of cell and gene therapies, which show g...
    DEC 15, 2020 10:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    DEC 15, 2020 10:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: December 15, 2020 TIME: 10:00am PST Scientists from Thermo Fisher Scientific will walk us through the world of microorganisms. They will discuss their most recent research on viruses,...
    JUN 09, 2020 10:00 AM PDT
    C.E. CREDITS
    JUN 09, 2020 10:00 AM PDT
    DATE: June 9, 2020 TIME: 10:00am PT, 1:00pm ET The presentation will first discuss sepsis as a disease and then explain the importance of performing diagnostic tests in the clinical labora...
    Loading Comments...
    Show Resources
    Attendees
    • See more