SEP 12, 2018 1:30 PM PDT

The NCTC 3000 Project: Mapping the Genetic Codes of 3000 Pathogenic Bacteria

Speaker

Abstract

Reducing the impact of infectious diseases is becoming increasingly vital as the prevalence of antimicrobial resistance (AMR) continues to rise, threatening the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses and fungi. The evolution of “superbugs” that can evade one or multiple drugs is one of the biggest threats facing medicine today. 

At the beginning of the 20th century a forward-thinking UK microbiologist, Dr Sir John Ledingham, recognised a need for a trustworthy source of globally-available authentic bacteria for scientific studies and went on to establish the National Collection of Type Cultures (NCTC) in 1920. This collection of live clinically-significant bacteria, encompassing strains isolated during the 19th century alongside those from the present day, represents a history of bacterial pathogens that cannot be replicated in a modern post-antibiotic environment. 

By using long read whole genome sequencing technology, the team responsible for curating and operating NCTC collaborated with molecular scientists at the Wellcome Sanger Institute in decoding the DNA of more than 3000 reference strains of pathogenic bacteria, many of which cause deadly diseases such as plague, dysentery, cholera and tuberculosis. This project has provided genomic data that researchers will be able to use to better understand these diseases and how they become resistant to antibiotics. The publicly available genomic maps support the development of new diagnostic tests, vaccines and treatments.
 

Learning Objectives: 

1. Understand the value of a culture collection in biomedical research
2. Recognise the significance of historical strains in understanding microbial evolution
3. Recognise some of the benefits of long read sequencing techniques for delivering reference genomes for pathogenic bacteria 


Show Resources
You May Also Like
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
DEC 09, 2021 11:00 AM PST
C.E. CREDITS
DEC 09, 2021 11:00 AM PST
Date: December 09, 2021 Time: 11:00am (PDT), 2:00pm (EDT) The burden of antimicrobial resistance (AMR) has been acknowledged worldwide by leading health institutes. Besides the need for new...
NOV 09, 2021 11:00 AM PST
C.E. CREDITS
NOV 09, 2021 11:00 AM PST
Date: November 09, 2021 Time: 11:00am (PDT), 02:00pm (EDT) Clinical translation of human pluripotent stem cells (hPSCs) requires advanced strategies that ensure safe and robust long-term gro...
OCT 20, 2021 10:00 AM PDT
C.E. CREDITS
OCT 20, 2021 10:00 AM PDT
Date: October 20, 2021 Time:10:00am (PDT), 1:00pm (EDT) As the prevalence of Diabetes continues to rise in many areas across the globe, healthcare providers continue to look for methods that...
NOV 17, 2021 8:00 AM PST
C.E. CREDITS
NOV 17, 2021 8:00 AM PST
Date: November 17, 2021 Time: 8:00am (PDT), 11:00am (EDT) From waste disposal to promising biomarkers and therapeutic agents, exosomes and other extracellular vesicles are valuable in resear...
JAN 13, 2022 9:00 AM PST
C.E. CREDITS
JAN 13, 2022 9:00 AM PST
Date: January 13, 2022 Time: 09:00am (PST), 12:00pm (EST) Recently, the Infectious Disease Society of America released guidance on how to approach treatment of infections caused by multidrug...
SEP 12, 2018 1:30 PM PDT

The NCTC 3000 Project: Mapping the Genetic Codes of 3000 Pathogenic Bacteria



Show Resources
Loading Comments...
Show Resources