OCT 12, 2017 01:30 PM PDT

Metabolic Regulation of Cell Fate Decisions

SPONSORED BY: Agilent
C.E. CREDITS: P.A.C.E. CE | Florida CE
Speakers
  • Assistant Member, Cell Biology Department, Memorial Sloan Kettering Cancer Center
    Biography
      Lydia Finley is an Assistant Member in the Cell Biology Program at Memorial Sloan Kettering Cancer Center. Dr. Finley received her BS from Yale University and then completed her PhD in the laboratory of Dr. Marcia Haigis at Harvard Medical School. As a postdoctoral fellow in the laboratory of Dr. Craig Thompson at Memorial Sloan Kettering Cancer Center, Dr. Finley identified metabolites that contribute to the regulation of stem cell self-renewal. Her current work investigates the mechanisms that link metabolic pathways to cell fate decisions. She is the recipient of the Jack Sorrell Fellowship of the Damon Runyon Cancer Research Foundation and the Dale F. Frey Award for Breakthrough Scientists.

    Abstract:

    The deposition and removal of DNA and histone modifications depends on the availability of specific metabolites, suggesting that cellular metabolic pathways may dynamically regulate chromatin modifications and gene expression. However, whether changes in metabolic flux can influence cell fate decisions is poorly understood. Dr. Finley’s research focuses on understanding how cell type-specific metabolic profiles contribute to the establishment and regulation of cell identity. In her seminar, Dr. Finley will present recent work illustrating how the metabolic wiring of embryonic stem cells promotes an open chromatin landscape and the maintenance of pluripotency. These results reveal that intracellular metabolic pathways play a mechanistic role in the transcriptional and epigenetic state of stem cells.

    For Research Use Only. Not for use in diagnostic procedures.
     


    Show Resources
    You May Also Like
    SEP 05, 2019 04:00 PM CEST
    C.E. CREDITS
    SEP 05, 2019 04:00 PM CEST
    DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
    JUN 05, 2019 05:00 PM CEST
    C.E. CREDITS
    JUN 05, 2019 05:00 PM CEST
    DATE: June 5, 2019TIME: 8:00am PDT, 11:00am EDT, 5:00pm CEST Eukaryotic cell cultures respond to the most subtle influence. Apart from the risk of contamination, minimal chan...
    MAY 16, 2019 04:00 PM CEST
    C.E. CREDITS
    MAY 16, 2019 04:00 PM CEST
    DATE: May 16, 2019TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST The emergence of NGS is revolutionizing the microbiological sciences and transforming medicine. Deep sequencing has...
    NOV 18, 2019 07:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    NOV 18, 2019 07:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: November 18, 2019TIME: 7:00am PST, 11:00am EST, 4:00pm CEWT How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop th...
    AUG 27, 2019 09:00 AM PDT
    C.E. CREDITS
    AUG 27, 2019 09:00 AM PDT
    DATE: August 27, 2019 TIME: 9:00am PDT, 12:00pm EDT Immunotherapies targeting PD-1 or PD-L1 have proven remarkably effective for treating cancer in some patients, with considerabl...
    JUN 19, 2019 10:00 AM PDT
    JUN 19, 2019 10:00 AM PDT
    DATE: June 19, 2019TIME: 10:00am PDT, 1:00pm EDT As we develop new methods to create more biologically relevant models for research in understanding disease etiology and in...
    Loading Comments...
    Show Resources