FEB 27, 2019 12:00 PM PST

Nanostructured Molecularly Imprinted Polymers: Robust, Stable and Selective Alternatives to Antibodies

Presented at: Drug Discovery 2019
Speaker

Abstract

NanoMIPs, often called “plastic antibodies”, are made using a proprietary self-assembly process where the template molecule is incubated with monomers, each of which is free in solution to adopt its optimal binding position, followed by a polymerisation step. By closely controlling the polymerisation, we have the ability to manufacture discrete nanoparticles typically with a single binding site, or imprint, of the template molecule. Each imprint is the correct “size and shape” for the target molecule and also have the corresponding complementary chemical functionality to enhance binding: H-bond acceptor for H bond donor etc. Once synthesised the nanoMIPs can be collected according to their affinity for the target (typically in the low nM range), or indeed to a selectivity target to meet the needs of the application. Furthermore, having a polyethylene backbone, nanoMIPs are extremely robust and highly resistant to pH, solvents and temperature. It is even possible to autoclave nanoMIPs without loss of function. 

Learning Objectives: 

1. Learn how synthetic polymer based nanoparticles can be developed as an alternative affinity reagent to antibodies.
2. Learn how these nanoMIPs have been applied to a range of different projects from epitope mapping, imaging and sensor development to drug delivery


Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
OCT 20, 2021 10:00 AM PDT
C.E. CREDITS
OCT 20, 2021 10:00 AM PDT
Date: October 20, 2021 Time:10:00am (PDT), 1:00pm (EDT) As the prevalence of Diabetes continues to rise in many areas across the globe, healthcare providers continue to look for methods that...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
OCT 12, 2021 9:00 AM PDT
C.E. CREDITS
OCT 12, 2021 9:00 AM PDT
Date: October 12, 2021 Time: 9:00am (PDT), 12:00pm (EDT) SCIEX’s next-generation Biologics Explorer software is an innovative platform for the comprehensive and deep characterization o...
AUG 24, 2021 11:00 AM PDT
C.E. CREDITS
AUG 24, 2021 11:00 AM PDT
Date: August 24, 2021 Time: 11:00am (PDT), 1:00pm (EDT) Electron-based dissociation mechanisms have shown great promise for advanced characterization of biomolecules. However, routine adopti...
FEB 27, 2019 12:00 PM PST

Nanostructured Molecularly Imprinted Polymers: Robust, Stable and Selective Alternatives to Antibodies

Presented at: Drug Discovery 2019

Specialty

Research

Research And Development

Earth Science

Immunology

Clinical Medicine

Nanoscience

Drug Development

Nanoparticles

Pcr/rt-Pcr/real-Time Pcr

Materials Science

Cell Signaling / Transduction

Chronic Pain

Cancer Therapeutics

Personalized Medicine

Health

Geography

North America63%

Asia13%

Europe13%

Africa13%

Registration Source

Website Visitors100%

Job Title

Student33%

Clinical Laboratory Scientist17%

Medical Laboratory Technician17%

Post Doc17%

Chemist17%

Organization

Academic Institution50%

Hospital13%

Manufacturer - Other13%

Other25%


Show Resources
Loading Comments...
Show Resources