FEB 27, 2019 12:00 PM PST

Nanostructured Molecularly Imprinted Polymers: Robust, Stable and Selective Alternatives to Antibodies

Presented at: Drug Discovery 2019
Speaker
  • CEO, MIP Diagnostics
    Biography
      Adrian Kinkaid is CEO of MIP Diagnostics (www.mip-dx.com ) which was founded in 2015 to commercialise nano-structured molecularly imprinted polymers, nanoMIPs or "plastic antibodies". Since joining Abcam in 2010, as Head of Technology Access, Adrian has worked with all the major forms of affinity reagents (antibodies, aptamers, affinity proteins and MIPs). Prior to this, he lead Drug Discovery teams at Lectus Therapeutics, Inpharmatica, Biofocus and Celltech Chiroscience (now UCB). He has a PhD in Biochemistry from Southampton and has twice served as Chairman of ELRIG: the European Laboratory Research & Innovation Group.

    Abstract

    NanoMIPs, often called “plastic antibodies”, are made using a proprietary self-assembly process where the template molecule is incubated with monomers, each of which is free in solution to adopt its optimal binding position, followed by a polymerisation step. By closely controlling the polymerisation, we have the ability to manufacture discrete nanoparticles typically with a single binding site, or imprint, of the template molecule. Each imprint is the correct “size and shape” for the target molecule and also have the corresponding complementary chemical functionality to enhance binding: H-bond acceptor for H bond donor etc. Once synthesised the nanoMIPs can be collected according to their affinity for the target (typically in the low nM range), or indeed to a selectivity target to meet the needs of the application. Furthermore, having a polyethylene backbone, nanoMIPs are extremely robust and highly resistant to pH, solvents and temperature. It is even possible to autoclave nanoMIPs without loss of function. 

    Learning Objectives: 

    1. Learn how synthetic polymer based nanoparticles can be developed as an alternative affinity reagent to antibodies.
    2. Learn how these nanoMIPs have been applied to a range of different projects from epitope mapping, imaging and sensor development to drug delivery


    Show Resources
    You May Also Like
    MAY 11, 2021 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    MAY 11, 2021 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
    NOV 18, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 18, 2020 8:00 AM PST
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    APR 01, 2021 8:00 AM PDT
    C.E. CREDITS
    APR 01, 2021 8:00 AM PDT
    Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
    NOV 16, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 16, 2020 8:00 AM PST
    Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
    DEC 02, 2020 8:00 AM PST
    C.E. CREDITS
    DEC 02, 2020 8:00 AM PST
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    JUN 09, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    JUN 09, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
    FEB 27, 2019 12:00 PM PST

    Nanostructured Molecularly Imprinted Polymers: Robust, Stable and Selective Alternatives to Antibodies

    Presented at: Drug Discovery 2019

    Specialty

    Research

    Research And Development

    Earth Science

    Immunology

    Clinical Medicine

    Nanoscience

    Drug Development

    Nanoparticles

    Pcr/rt-Pcr/real-Time Pcr

    Materials Science

    Cell Signaling / Transduction

    Chronic Pain

    Cancer Therapeutics

    Personalized Medicine

    Health

    Geography

    North America50%

    Asia13%

    Europe13%

    Africa13%

    Registration Source

    Website Visitors100%

    Job Title

    Student33%

    Clinical Laboratory Scientist17%

    Medical Laboratory Technician17%

    Post Doc17%

    Chemist17%

    Organization

    Academic Institution50%

    Hospital13%

    Manufacturer - Other13%

    Other25%


    Show Resources
    Loading Comments...
    Show Resources
    Attendees
    • See more