FEB 27, 2019 12:00 PM PST

Nanostructured Molecularly Imprinted Polymers: Robust, Stable and Selective Alternatives to Antibodies

Presented at: Drug Discovery 2019
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • CEO, MIP Diagnostics
    Biography
      Adrian Kinkaid is CEO of MIP Diagnostics (www.mip-dx.com ) which was founded in 2015 to commercialise nano-structured molecularly imprinted polymers, nanoMIPs or "plastic antibodies". Since joining Abcam in 2010, as Head of Technology Access, Adrian has worked with all the major forms of affinity reagents (antibodies, aptamers, affinity proteins and MIPs). Prior to this, he lead Drug Discovery teams at Lectus Therapeutics, Inpharmatica, Biofocus and Celltech Chiroscience (now UCB). He has a PhD in Biochemistry from Southampton and has twice served as Chairman of ELRIG: the European Laboratory Research & Innovation Group.

    Abstract

    NanoMIPs, often called “plastic antibodies”, are made using a proprietary self-assembly process where the template molecule is incubated with monomers, each of which is free in solution to adopt its optimal binding position, followed by a polymerisation step. By closely controlling the polymerisation, we have the ability to manufacture discrete nanoparticles typically with a single binding site, or imprint, of the template molecule. Each imprint is the correct “size and shape” for the target molecule and also have the corresponding complementary chemical functionality to enhance binding: H-bond acceptor for H bond donor etc. Once synthesised the nanoMIPs can be collected according to their affinity for the target (typically in the low nM range), or indeed to a selectivity target to meet the needs of the application. Furthermore, having a polyethylene backbone, nanoMIPs are extremely robust and highly resistant to pH, solvents and temperature. It is even possible to autoclave nanoMIPs without loss of function. 

    Learning Objectives: 

    1. Learn how synthetic polymer based nanoparticles can be developed as an alternative affinity reagent to antibodies.
    2. Learn how these nanoMIPs have been applied to a range of different projects from epitope mapping, imaging and sensor development to drug delivery


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