MAR 19, 2015 01:30 PM PDT

Neural Circuits Important for Valence Processing

Presented At Neuroscience
Speakers
  • Principal Investigator, Picowar Institute, Assistant Professor of Neuroscience, Department of Brain and Cognitive Sciences, MIT
    Biography
      Kay Tye began her education as an undergraduate research assistant at MIT from 1999-2003. She continued her studies at the University of California, San Francisco as a graduate student in Patricia Janaks lab studying electrophysiological properties of amygdala neurons both in vivo and ex vivo during reward-seeking behavior. Kay then did a short postdoc with Antonello Bonci, now the intramural director of NIDA, to study synaptic strength following reward learning, followed by a postdoc at Stanford University with Karl Deisseroth where she used novel optogenetic techniques to dissect the neural circuitry underlying psychiatric disease. Kay is currently an Assistant Professor at Massachusetts Institute of Technology in the Picower Institute for Learning and Memory, a member of the Department of Brain and Cognitive Sciences. She is also a NYSCF Neuroscience Robertson Investigator
      <br />

    Abstract:

    Behaviors are motivated by two emotional valences: Seeking pleasure and avoiding pain. The ability to select appropriate behavioral responses to environmental stimuli, such as avoiding a predator or approaching a food source, is critical for survival. The perturbation of valence processing is also relevant to a number of psychiatric disease states. Within a given type of behavior, such as feeding or social interaction, motivational drives of both positive and negative valence can contribute. For example, feeding can be driven by the rewarding aspects of food consumption or by the motivation to escape the aversive state of hunger. Recent insights from our lab outline a diverse set of circuit-level processes that can modulate valence in a given behavior. We hope these basic science insights will lead to the development of more effective and specific therapeutics capitalizing on a solid understanding of neural circuitry.


    Show Resources
    You May Also Like
    MAY 24, 2018 09:30 AM PDT
    C.E. CREDITS
    MAY 24, 2018 09:30 AM PDT
    DATE: May 24, 2018 TIME: 9:30PM PDT The current gold standard in in vitro pre-clinical cancer treatment screening remain cell lines,...
    MAY 03, 2018 11:00 AM PDT
    MAY 03, 2018 11:00 AM PDT
    DATE: May 3, 2018TIME: 11:00AM PDT, 2:00PM EDTWhile stress is one of the leading causes of neuropsychiatric disorders, the molecular underpinnings of how stress induces alterations in b...
    MAY 22, 2018 08:00 AM PDT
    C.E. CREDITS
    MAY 22, 2018 08:00 AM PDT
    DATE: May 22, 2018TIME: 08:00AM PDT The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are closely related transcription factors that...
    APR 27, 2018 10:00 AM PDT
    C.E. CREDITS
    APR 27, 2018 10:00 AM PDT
    DATE: April 27, 2018TIME: 10:00am PST, 1:00pm ESTGlioblastoma (GBM) and Medulloblastoma (MB) are the most common adult and paediatric brain tumours, both of which can have devastating c...
    AUG 15, 2018 08:00 AM PDT
    C.E. CREDITS
    AUG 15, 2018 08:00 AM PDT
    DATE: August 15, 2018TIME: 08:00AM PDT, 11:00AM EDTThe failure of current chemotherapeutic strategies in the fight against cancer can be largely attributed to the occurrence of drug res...
    JUN 26, 2018 06:00 AM PDT
    C.E. CREDITS
    JUN 26, 2018 06:00 AM PDT
    Date: June 26, 2018Time: 6:00 a.m. PDT, 9:00 a.m. EDT, 1500 CEST Today’s hematology analyzers employ various methods for enumerating platelets. These methods include: e...
    Loading Comments...