The NIH BRAIN Initiative aims to develop new tools and neurotechnologies to transform our understanding of brain function in health and disease. That knowledge is critical to enable novel therapies for brain disorders, which cause immense suffering and have a major economic impact worldwide. Our ability to intervene medically is hampered by limited understanding of how brain circuits go awry in disorders such as dementia, chronic pain, addiction, and autism. The powerful technological advances catalyzed by the BRAIN Initiative will allow us to record and modulate brain circuit function in unprecedented ways, which will pose a number of ethical questions. Neuroethics is essential for the success of the NIH BRAIN Initiative, and for neuroscience research more broadly, because it enables advance consideration of the ethical, legal, and societal implications of neuroscience research. This facilitates progress in neuroscience and helps ensure that neuroscientific advancements support human well-being. From its inception the NIH BRAIN Initiative has made a concerted effort to integrate neuroethics into its science. Integrating neuroethics into the Initiative serves the interests of all involved stakeholders, and requires collaborative input from many disciplines – neuroscience, medicine, bioethics, philosophy, law, and others. This talk will present a brief introduction to neuroethics and an overview of the NIH BRAIN Initiative’s neuroethics strategy and program, including funding for neuroethics research.