AUG 20, 2014 08:45 AM PDT

Novel gene chip technologies and NGS sequencing for personalized medicine & diagnostic

Speakers
  • Professor, Scientific Director, Head of MSc program in Biotechnology, Tel Hai College, GGA - Galil Genetic Analysis
    Biography
      Prof' Bercovich expertise are the specialization in preforming complex genetic screening in humans genomic DNA, which were acquired during his post-doctoral in the Baylor College of Medicine, Houston, Texas, which was  one of the five major human genome project centers. When the genomic location of a genomic component (loci - gene) is unknown, Prof; Bercovich is  assisted by using linkage testing techniques (genetic chips with SNP) and then using the techniques of sequencing of the entire EXOM to reveal new genes for human diseaseNew gene mutations, which were identified in laboratory studies of Prof. Bercovich, were used for intracellular studies in the laboratory, and identified the biological effects of those changes. Professor Bercovich working in recent years to develop new diagnostic methods using genetic chips and has resulted in the development stages and final clinical validation of genetic chips for prenatal screening and common mutations which defend predisposition peoples to genetic diseases & cancers, using the Fluidigm nano-chips, by careful planning using higher density of nanometers Taqman reactions. The combination of advances in genetics research in general and human genetics in particular, and the development of various techniques of laboratory tests, led the field of bioinformatics as a center stage to preform quality of laboratory work, and this is a key process in today's medical interpreting test results in research, and in medical services. Professor Bercovich bought himself a place in recent years, to be one of the leading groups in this country; he acquired vast experience in the field and is considered a noticeable expert in the field of molecular Genetics.Prof' Bercovich has publish of 60 pear review articles in high impact factors journals including The Lancet (Bercovich et al Lancet, 2008).

    Abstract:

    The flexibility of the BioMark Real-Time PCR System, allow us to preform genetic research using different types of nano-fluidic (48.48 or 96.96) chips setup, in the thermal cycle of these chips and image the data in real time for quantity determination of DNA copy numbers (CNV) or mRNA expression in multiple loci locations or genes, and can also to be used as an endpoint image reader for analyzing different allelic genotyping frequencies like in a panel of 92 most common mutations, in the Israeli populations, for 42 different mono genetic disorders, and 15-14 common mutations in Breast/Ovarian and Colon cancers.
    Digital-PCR gene chip were used to determine the number of a human gene which were incorporated in a plant cells for the production of this protein to treat human disease. CGH array and next-generation sequencing (NGS) technologies has reduced sequencing cost by orders of magnitude and significantly increased the throughput, making whole-exom sequencing a possible way for obtaining global genomic information about patients on whom clinical actions may be taken and were used to locate new genes associated with complex clinical genetic diseases. Tumors genetic is define using OnocoScan gene chip and the nano-fluidic gene chips by RT-PCR reactions on several most common somatic mutations to define most suitable chemotherapy treatments in different cancers types.


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