OCT 26, 2011 2:00 PM PDT

Novel Solutions for Detection and Measurement of Autophagy: Applications for drug discovery & development

Speaker

Abstract

 

Autophagy is a normal degradative pathway that involves the sequestration of entire organelles, protein complexes, and misfolded proteins in a membrane vacuole called the autophagosome. The autophagosomal vesicle is subsequently delivered to the lysosome where it is degraded into its essential constituents and recycled back to the cytoplasm. Autophagy plays an important role in diverse biological events, not only during conditions of nutrient limitation, but it also functions in tumor suppression, the immune response, and the prevention of certain types of neurodegeneration. In this presentation, I will review several unique tools from Enzo for measuring autophagy, including new ELISA kits for the autophagy biomarkers p62 and NBR1, as well as dye-based assays for quantifying autophagy in live cells.

 


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