MENU
NOV 09, 2017 6:00 AM PST

Organoid Technology - from Adult Stem Cells to Miniature Organs

Speaker
  • Postdoctoral Researcher, Hubrecht Institute for Developmental Biology and Stem Cell Research
    Biography
      Helmuth Gehart received his PhD from ETH Zurich (Zurich, Switzerland) in 2013. During his PhD training with Prof. Romeo Ricci, Helmuth studied the mechanisms behind Type II Diabetes and the complex cellular checkpoints that maintain balance to prevent disease. Thereafter, Helmuth aimed to combine his knowledge of signaling and metabolism with the fascinating field of stem cell biology. Thus, he joined the group of Prof. Hans Clevers at the Hubrecht Institute (Utrecht, Netherlands). There he investigates adult tissue stem cells of the liver and their use in clinical research and regenerative medicine.

    Abstract

    Adult stem cell research is one of the most dynamic and fast growing fields of our time. Investigating how organs maintain and repair themselves has led to the discovery of cell populations throughout the body that hold immense regenerative capacity. For a long time, research on adult stem cells has been held back by the inability to grow and study these cells in vitro. This limitation has finally been overcome with the development of organoid technology, a system that enables us to grow single adult stem cells into self-organizing miniature organs. These organoids perform many functions of their parent tissue and are excellent tools to study organ regeneration, organ function and disease development. This presentation provides an overview of the many contributions the team around Hans Clevers has made to the development of organoid culture and delves into applications of the technology in disease modeling, pharmacological screening, regenerative medicine and cancer research.


    Show Resources
    You May Also Like
    JAN 23, 2020 9:00 AM PST
    C.E. CREDITS
    JAN 23, 2020 9:00 AM PST
    DATE: January 23, 2020 TIME: 9:00am PST, 12:00pm EST...
    APR 07, 2020 8:00 AM PDT
    C.E. CREDITS
    APR 07, 2020 8:00 AM PDT
    DATE: April 7, 2020 TIME: 8:00am PT, 11:00am ET This webinar sets out to establish why quality control is key to robust, reliable, reproducible science. We will look at best practice criteri...
    FEB 26, 2020 9:00 AM PST
    C.E. CREDITS
    FEB 26, 2020 9:00 AM PST
    DATE: February 26, 2020 TIME: 9:00am PST 3D cell culture and analysis and the study of organoids and spheroids are becoming more prevalent as a research method in publications as traditional...
    FEB 25, 2020 9:00 AM PST
    C.E. CREDITS
    FEB 25, 2020 9:00 AM PST
    Learn about how to generate a small scale CAR-T workflow using ThermoFisher products See detailed characterization tools that can be utilized and applied in a CAR-T workflow...
    MAR 03, 2020 9:00 AM JST
    C.E. CREDITS
    MAR 03, 2020 9:00 AM JST
    DATE: March 3, 2020 TIME: 9:00am JST A major limitation in the ex vivo expansion of harvested human hematopoietic stem-progenitor cells (HSPCs) is the rapid differentiation of HSPCs at the e...
    MAY 08, 2020 10:00 AM PDT
    C.E. CREDITS
    MAY 08, 2020 10:00 AM PDT
    DATE: May 8, 2020 TIME: 10:00am PT, 11:00am MT, 1:00pm ET The application of next generation sequencing to interrogate immune repertoires and methods in which these highly complex dataset...
    Loading Comments...
    Show Resources
    Attendees
    • See more