JUN 20, 2019 10:30 AM PDT

Outlier Kinases as Targets for Precision Therapy

Speakers
  • Research Assistant Professor of Urology, Northwestern University, Feinberg School of Medicine
    Biography
      The overall theme of my research is to identify, characterize and target the genes that help in the progression of aggressive prostate cancers. During my postdoctoral fellowship, I developed novel approaches to identify outlier kinases in breast and pancreatic cancer and studied the role of these kinases in oncogenic progression. I continued to apply this novel matrix to identify novel biomarkers to distinguish indolent from aggressive prostate cancer and to interrogate therapeutic targets in advanced prostate cancer. Apart from identifying biomarkers and therapeutic targets, I also have an expertise in delineating oncogenic signaling and resistance mechanisms and carry out translational research. My goal is to delineate the molecular and biological differences between the prostate cancers in African-American and Caucasian men, to help progress the field towards personalized medicine.

    Abstract:

    In this presentation, Dr. Kothari will provide an overview of the Precision Medicine Initiative from NIH and how NGS technologies have helped the researchers to look deep inside the human transcriptome. Focusing on kinases, Dr. Kothari will discuss the sample centric versus gene centric approaches to analyze the transcriptome data to identify new drug targets. He will finally share his thoughts on how integrative omics approaches can help researchers find better drug targets and robust biomarkers of disease progression, that will help in achieving the goals of precision medicine initiative. 

    Learning Objectives: 

    1. To understand the merit of sample centric transcriptome analysis to identify new drug targets using NGS.
    2. To understand the merit of gene centric transcriptome analysis to identify new drug targets using nGS.
     


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