JAN 30, 2020 08:00 AM PST
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Path Forward of Mass Spectrometry in Clinical Laboratories

Speakers
  • Assistant Professor of Clinical Pathology and Genomic Medicine, Institute for Academic Medicine, Houston Methodist, Weill Cornell Medical College
    Biography
      Dr. Xin Yi is a board-certified clinical chemist (DABCC) with broad expertise in clinical chemistry, clinical immunology, endocrinology testing, therapeutic drug monitoring, and clinical pharmacogenetics. She is a fellow of the AACC's National Academy of Clinical Biochemistry (NACB), and the Co-director of the clinical chemistry laboratory at Houston Methodist Hospital. Dr. Yi is interested in the application of new technologies, especially mass spectrometry and genetic analysis, in broader clinical diagnostic use. Her past research activities focused on developing novel LC-MS assays for hormone, drug and protein measurements. Her studies in pharmacogenetics involved understanding the impact of genetic variations on therapeutic responses, such as responses to anticoagulant and antiplatelet agents, Warfarin and Clopidogrel. Her current researches are focused on studying the expression of onco-proteins in tumor tissues using mass spectrometry, and studying novel biomarkers in kidney diseases.

    Abstract:

    DATE: January 30, 2020
    TIME: 8:00am PST

    In the recent decade, mass spectrometry has become the method of choice for certain laboratory tests, like steroid hormones, pain management drugs, and some small proteins/peptides analysis. As a common concern, measurements of steroid molecules and protein biomarkers in the clinical laboratory suffer from inaccuracy at low levels and poor specificity, due to a variety of interfering metabolites and binding proteins. Accurate and reliable analysis is often of essential importance on disease diagnosis and treatment. Mass spectrometry provides advantages of analyzing steroids and proteins with high sensitivity and specificity, thus improves laboratory test quality for clinical use. With emerging new techniques in mass spectrometry, its application can be expanded to more areas, including more comprehensive protein biomarker analysis and multiplex analysis with computer algorithm. The continuous development and implementation of mass spectrometry start to change clinical laboratory more substantially, and also start to change clinical operations even outside the laboratories.

     

    Learning Objectives:

    • Explain current trends of mass spectrometry in clinical applications
    • Discuss the streamline mass spectrometry operation process to meet practical challenges
    • Describe how emerging techniques allow robust mass spectrometry testings with high throughput and high efficiency

     

    Webinars will be available for unlimited on-demand viewing after live event.

     

    LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


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