MAY 30, 2018 6:00 AM PDT

Phenotypic Profiling for Improving Drug Discovery Productivity

Presented at: Lab Automation 2018
Speaker

Abstract

The pharmaceutical industry’s productivity crisis is well known with >90% of drug candidates failing in clinical testing, primarily due to unexpected toxicity or lack of efficacy.  Despite advances in high throughput ‘omics technologies and the large volume of information that is now amassed on new drug candidates, the probability of success for new molecules is not improving.  Scannel and Bosney (2016) have pointed to a lack of predictive preclinical models as one of the key factors.  New approaches using human-based in vitro cell systems are showing promise for replacing the use of animal models, particularly in cases where animal testing has failed to predict human effects. These new approaches will be described along with case studies that illustrate how these methods can generate mechanistic hypotheses for drug induced cardiovascular toxicity.  Also to be discussed is how phenotypic assay data may be incorporated into safety risk assessments through the adverse outcome pathway framework being developed for chemical safety testing.


Learning Objectives: 

1. Learn about non-animal based in vitro assays for preclinical testing in drug discovery.
2. Review some of the factors that make it challenging to predict drug efficacy in clinical testing.
3. Find out about new hypotheses underlying cardiovascular disease and drug induced cardiotoxicity.


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MAY 30, 2018 6:00 AM PDT

Phenotypic Profiling for Improving Drug Discovery Productivity

Presented at: Lab Automation 2018

Specialty

Research And Development

Research

Molecular Biology

Disease

Molecular Genetics

Brain

Animal Sciences

Health

Behavioral Research

Gene

Molecular Neuroscience

Drug Development

Pcr/rt-Pcr/real-Time Pcr

Earth Science

Immunity

Geography

North America67%

Asia33%

Registration Source

Website Visitors100%

Job Title

Medical Laboratory Technician33%

Scientist33%

Lab Management33%

Organization

Clinical Laboratory33%

Manufacturer - Other33%

Contract Research Organization (Cro)33%


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