MENU

Pluripotent stem cell bioprocessing platforms for cell therapy manufacturing

Speaker
  • Senior Process Development Scientist, Cell and Gene Therapy Catapult
    Biography
      Jahid is a Senior Process Development Scientist at the Cell and Gene Therapy Catapult where he has been working for the last 4 years on various upstream and downstream development projects including the Cell Plasticity platform programme. He holds a doctorate degree from the University of Leeds where he developed a method for decellularising porcine meniscus with bone blocks for use as a meniscal replacement therapy. Jahid completed the Biochemical Engineering undergraduate programme at University College London gaining an MEng degree during which he undertook a year of work at Lonza's Cell Culture Process Development team in Slough-UK. Here, he assessed medium formulation and stability on CHO cell culture.

    Abstract

    Pluripotent stem cell (PSC) culture at commercial scale requires a shift from the current manual processing methods and costly materials to deliver affordable differentiated cell products in a repeatable and robust manner. The development of automated processing and analytical platforms for manufacturing allogeneic cell therapies derived from pluripotent stem cells is one of the aims of the Industrialisation group of the Cell and Gene Therapy Catapult (CGTC). This is centred around developing starting materials compliant with industry-standards, scalable 2D and 3D expansion systems as well as flexible downstream processing solutions. Here, we describe the current progress of CGTC’s Cell Plasticity platform programme with respect to developing automated processes for controlled expansion of pluripotent stem cells in 2D and 3D systems and strategies for culture intensification and integrated downstream processing solutions.


    Show Resources
    You May Also Like
    DEC 02, 2020 8:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    DEC 02, 2020 8:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    OCT 08, 2020 7:00 AM PDT
    C.E. CREDITS
    OCT 08, 2020 7:00 AM PDT
    DATE: October 8, 2020 TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop thinking about ho...
    JUN 23, 2020 10:00 AM PDT
    C.E. CREDITS
    JUN 23, 2020 10:00 AM PDT
    DATE: June 23, 2020 TIME: 10:00am PT Human mesenchymal stromal or stem cells (MSCs)-based immunomodulation treatment has been proposed as a suitable therapeutic approach for many diseases, s...
    SEP 10, 2020 9:00 AM PDT
    C.E. CREDITS
    SEP 10, 2020 9:00 AM PDT
    Date: September 10, 2020 Time: 9:00am (PDT), 12:00pm (EDT) Osmolality testing is relevant throughout the entire bioprocessing workflow. As customers look to refine mAb and gene therapy workf...
    AUG 25, 2020 8:00 AM PDT
    C.E. CREDITS
    AUG 25, 2020 8:00 AM PDT
    DATE: August 25, 2020 TIME: 8:00am PDT, 10:00am CDT, 11:00am EDT Recombinant lentivirus (LV) and adeno-associated virus (AAV) are critical components of cell and gene therapies, which show g...
    DEC 09, 2020 9:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    DEC 09, 2020 9:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: December 09, 2020 TIME: 09:00am PDT Hematopoietic stem cells (HSCs) ensure homeostasis of blood throughout life. In this webinar, we share insights into the smart and easy isolation, c...
    Loading Comments...
    Show Resources
    Attendees
    • See more