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Pluripotent stem cell bioprocessing platforms for cell therapy manufacturing

Speaker
  • Senior Process Development Scientist, Cell and Gene Therapy Catapult
    Biography
      Jahid is a Senior Process Development Scientist at the Cell and Gene Therapy Catapult where he has been working for the last 4 years on various upstream and downstream development projects including the Cell Plasticity platform programme. He holds a doctorate degree from the University of Leeds where he developed a method for decellularising porcine meniscus with bone blocks for use as a meniscal replacement therapy. Jahid completed the Biochemical Engineering undergraduate programme at University College London gaining an MEng degree during which he undertook a year of work at Lonza's Cell Culture Process Development team in Slough-UK. Here, he assessed medium formulation and stability on CHO cell culture.

    Abstract

    Pluripotent stem cell (PSC) culture at commercial scale requires a shift from the current manual processing methods and costly materials to deliver affordable differentiated cell products in a repeatable and robust manner. The development of automated processing and analytical platforms for manufacturing allogeneic cell therapies derived from pluripotent stem cells is one of the aims of the Industrialisation group of the Cell and Gene Therapy Catapult (CGTC). This is centred around developing starting materials compliant with industry-standards, scalable 2D and 3D expansion systems as well as flexible downstream processing solutions. Here, we describe the current progress of CGTC’s Cell Plasticity platform programme with respect to developing automated processes for controlled expansion of pluripotent stem cells in 2D and 3D systems and strategies for culture intensification and integrated downstream processing solutions.


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