Post-translational Modifications and Data-Independent Acquisitions - Challenges and Opportunities

I am a Research Associate Professor with an independent laboratory and the Director of the Mass Spectrometry Core at the Buck Institute for Research on Aging. I am especially interested in protein chemistry and modern mass spectrometric technologies to advance the field of Proteomics mainly in the context of Aging Research. I am directly involved in a large variety of research projects (spanning neurodegenerative diseases, cancer, diabetes, mitochondrial damage, molecular mechanisms of aging, protein posttranslational modifications, bacterial pathogenesis etc.), and in mass spectrometric method development that will benefit biological projects. To date this work has resulted in 99 peer-reviewed publications. Several research projects include investigation of protein phosphorylation, glycosylation, acetylation, succinylation and other posttranslational modifications, as well as differential expression of proteins during disease and aging processes. I have collaborated on several projects specifically investigating mitochondrial acetylation and succinylation - and I have been working on different phosphorylation projects using various affinity enrichment strategies.

Matt Stokes began his scientific career in 1994 as a high school student with an internship at New England BioLabs/Cell Signaling Technology where he worked through college. He received his B.A. in Biology from Colby College in Waterville, ME in 2000. He then pursued his interest in understanding the complexities of cellular signaling pathways at Harvard University in Cambridge, MA where he received his Ph.D. in Biochemistry in 2005. During this time, his work focused on elucidating mechanisms of the DNA damage response using Xenopus laevis egg extracts. Matt joined Cell Signaling Technology in 2005 as a scientist in the Cancer Discovery group, and moved to the Proteomics Group in 2009. Matt currently leads the Proteomics Products and Services Group, providing start-to-finish proteomics solutions for both academic and industry clients.