FEB 24, 2016 11:00 AM PST

Precision Ferroptosis Inducers: Death by Lipid Peroxidation

Speaker
  • Professor, Columbia University, Departments of Biological Sciences and Chemistry
    Biography
      A decorated researcher, Stockwell is investigating mechanisms of cell death and exploring their application in the treatment of cancer and neurodegeneration. His investigations have not only identified drug candidates, they've inspired new methods of small molecule drug discovery. Stockwell is author of The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines.

    Abstract

    Cell death is involved in diseases such as cancer and neurodegeneration, and also has a natural role in the development of multicellular organisms. Although apoptosis has been well defined, alternative forms of cell death have been less explored. In my lab, we performed a global analysis of pharmacologically accessible cell death mechanisms using a strategy we refer to as modulatory profiling. Using this approach, we found compounds that induce apoptosis, necrosis, and a novel form of regulated cell death. These novel compounds induce a non-apoptotic, iron-dependent oxidative form of cell death that we refer to as ferroptosis. We have found that this form of cell death is distinct from apoptosis and necrosis on the basis of morphological, biochemical, genetic and inhibitor sensitivity data. In addition, we have used these compounds to elucidate the key mechanisms regulating ferroptosis, and to probe the relevance of ferroptosis to a variety of diseases and therapeutic applications. Finally, we have defined biomarkers that predict sensitivity and resistance to ferroptosis, opening the possibility of precision medicines that induce ferroptosis for treating a variety of cancers.

    Learning Objectives:
     
    1. Design experiments to test the mechanism of cell death occurring in a specific context
    2. Predict whether a specific patient will be sensitive to a drug that activates a specific type of cell death

     


    Show Resources
    You May Also Like
    SEP 10, 2020 9:00 AM PDT
    C.E. CREDITS
    SEP 10, 2020 9:00 AM PDT
    Date: September 10, 2020 Time: 9:00am (PDT), 12:00pm (EDT) Osmolality testing is relevant throughout the entire bioprocessing workflow. As customers look to refine mAb and gene therapy workf...
    DEC 02, 2020 8:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    DEC 02, 2020 8:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    NOV 18, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 18, 2020 8:00 AM PST
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    OCT 08, 2020 7:00 AM PDT
    C.E. CREDITS
    OCT 08, 2020 7:00 AM PDT
    DATE: October 8, 2020 TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop thinking about ho...
    NOV 16, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 16, 2020 8:00 AM PST
    Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
    OCT 29, 2020 6:00 AM PDT
    C.E. CREDITS
    OCT 29, 2020 6:00 AM PDT
    Date: October 29, 2020 Time: 6:00am (PDT), 9:00am (EDT), Chronic inflammation can occur as a result of a combination of genetic predispositions and environmental factors. Epigenetic modifica...
    Loading Comments...
    Show Resources
    Attendees
    • See more