FEB 24, 2016 11:00 AM PST

Precision Ferroptosis Inducers: Death by Lipid Peroxidation

Speaker

Abstract

Cell death is involved in diseases such as cancer and neurodegeneration, and also has a natural role in the development of multicellular organisms. Although apoptosis has been well defined, alternative forms of cell death have been less explored. In my lab, we performed a global analysis of pharmacologically accessible cell death mechanisms using a strategy we refer to as modulatory profiling. Using this approach, we found compounds that induce apoptosis, necrosis, and a novel form of regulated cell death. These novel compounds induce a non-apoptotic, iron-dependent oxidative form of cell death that we refer to as ferroptosis. We have found that this form of cell death is distinct from apoptosis and necrosis on the basis of morphological, biochemical, genetic and inhibitor sensitivity data. In addition, we have used these compounds to elucidate the key mechanisms regulating ferroptosis, and to probe the relevance of ferroptosis to a variety of diseases and therapeutic applications. Finally, we have defined biomarkers that predict sensitivity and resistance to ferroptosis, opening the possibility of precision medicines that induce ferroptosis for treating a variety of cancers.

Learning Objectives:
 
1. Design experiments to test the mechanism of cell death occurring in a specific context
2. Predict whether a specific patient will be sensitive to a drug that activates a specific type of cell death

 


Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
APR 01, 2021 8:00 AM PDT
C.E. CREDITS
APR 01, 2021 8:00 AM PDT
Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
MAR 18, 2021 8:00 AM PDT
C.E. CREDITS
MAR 18, 2021 8:00 AM PDT
DATE: March 18, 2021 TIME: 8:00am PDT Sequencing of bulk cells, single cells, and nuclei is opening doors in the understanding of complex biological processes....
JUL 28, 2021 8:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
C.E. CREDITS
JUL 28, 2021 8:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
Date: July 28, 2021 Time: 8:00am PDT Breast cancer is the most common form of cancer in women. It is estimated that 1 out of 8 women in the US will develop invasive breast cancer during her...
MAR 16, 2021 10:00 AM PDT
C.E. CREDITS
MAR 16, 2021 10:00 AM PDT
Date: March 16, 2021 Time: 10:00am (PST) Scientific progress and breakthroughs today are often too expensive for most institutions to acquire. Each year, the National Institutes of Health (N...
FEB 24, 2016 11:00 AM PST

Precision Ferroptosis Inducers: Death by Lipid Peroxidation


Specialty

Life Science

Health

Research And Development

Earth Science

University

Research

Geography

Asia100%

Registration Source

Website Visitors100%

Job Title

Medical Laboratory Technician100%

Organization

Clinical Laboratory50%

Manufacturer - Other50%


Show Resources
Loading Comments...
Show Resources
Attendees
  • See more