NOV 29, 2017 10:00 AM PST

WEBINAR: RAS Oncoproteins: Therapeutic Vulnerabilities

SPONSORED BY: Bio-Techne
C.E. CREDITS: P.A.C.E. CE | Florida CE
Speakers
  • Associate Professor of Radiation Oncology and Pharmacology, University of North Carolina at Chapell Hill
    Biography
      Adrienne D. Cox, PhD, is Chief of the Division of Cancer Research in the Department of Radiation Oncology at the University of North Carolina at Chapel Hill (UNC-CH), Associate Professor of Pharmacology, and a member of the Lineberger Comprehensive Cancer Center (LCCC), where she directs UNC-CH's NCI-funded Cancer Cell Biology T32 Training Program. Dr. Cox serves on numerous internal and external mentoring committees and grant review panels, reviewing for the National Cancer Institute (NCI) as well as nonprofit organizations such as the American Cancer Society and the Pancreatic Cancer Action Network. She received her BA from Pomona College, her PhD from Eastern Virginia Medical School, and performed her postdoctoral studies at the La Jolla Cancer Research Foundation (now the Sanford Burnham Prebys Medical Discovery Institute). She has been involved in the study of RAS proteins since the discovery of their lipid modification by prenylation, publishing over 100 articles in peer-reviewed journals and consulting over the years for numerous pharmaceutical companies. Dr. Cox's research encompasses basic science aspects of RAS family signaling and transformation as well as translational aspects such as the development of farnesyltransferase inhibitors, originally intended to be anti-RAS therapeutics. Her laboratory is a constituent of the RAS Synthetic Lethal Network, a component of NCI's RAS Initiative that seeks to identify and target RAS therapeutic vulnerabilities.

    Abstract:

    DATE: November 29, 2017
    TIME: 10:00 AM PST

    The three human RAS genes (HRAS, KRAS and NRAS) encode four highly related RAS small GTPases (HRAS, KRAS4A, KRAS4B and NRAS). RAS proteins function as GDP-GTP regulated binary on-off switches that regulate diverse cytoplasmic signaling networks. In cancer and developmental disorders (RASopathies), mutationally activated RAS proteins drive aberrant signal transduction.  RAS proteins are also the founding members of a large superfamily of small GTPases comprised of >150 members.  Since their initial identification decades ago as drivers of human cancers, there has been intense interest and effort in targeting RAS for cancer treatment. RAS genes are the most frequently mutated oncogenes in the top three causes of cancer deaths in the US in 2016 (lung, colorectal and pancreatic cancers).  In this webinar, I will discuss the vulnerabilities of RAS that have been exploited for the development of pharmacologic inhibitors of RAS function.

    Learning Objectives:

    • Understand RAS function in cytoplasmic signaling
    • Understand the  potential therapeutic role of anti-RAS therapy in Cancer

    Show Resources
    You May Also Like
    MAY 24, 2018 09:30 AM PDT
    C.E. CREDITS
    MAY 24, 2018 09:30 AM PDT
    DATE: May 24, 2018 TIME: 9:30PM PDT The current gold standard in in vitro pre-clinical cancer treatment screening remain cell lines,...
    MAY 02, 2018 08:00 AM PDT
    C.E. CREDITS
    MAY 02, 2018 08:00 AM PDT
    Immunohistochemistry protocols, which utilize antibodies to visualize proteins in tissue sections, have many steps that need optimized to prevent non-specific background effects, artifacts, o...
    MAY 24, 2018 09:00 AM PDT
    C.E. CREDITS
    MAY 24, 2018 09:00 AM PDT
    Recent advances in immuno-oncology research has proven the critical role of immune cells in cancer therapy. Deep understanding of the interaction and phenotype of immune and tumor cells withi...
    MAY 29, 2018 09:00 AM PDT
    C.E. CREDITS
    MAY 29, 2018 09:00 AM PDT
    Recent advances in immuno-oncology research has proven the critical role of immune cells in cancer therapy. Deep understanding of the interaction and phenotype of immune and tumor cells withi...
    APR 27, 2018 10:00 AM PDT
    C.E. CREDITS
    APR 27, 2018 10:00 AM PDT
    DATE: April 27, 2018TIME: 10:00am PST, 1:00pm ESTGlioblastoma (GBM) and Medulloblastoma (MB) are the most common adult and paediatric brain tumours, both of which can have devastating c...
    AUG 15, 2018 08:00 AM PDT
    C.E. CREDITS
    AUG 15, 2018 08:00 AM PDT
    DATE: August 15, 2018TIME: 08:00AM PDT, 11:00AM EDTThe failure of current chemotherapeutic strategies in the fight against cancer can be largely attributed to the occurrence of drug res...
    Loading Comments...